Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19411046 | 1.00 | DHODH (0.46) | DHODHKDRBRAFEPHX2ALDH1A1 | |
| SCHEMBL7383350 | 0.88 | DHODH (0.51) | DHODHKDRBRAFEPHX2ALDH1A1 | |
| SCHEMBL28139470 | 0.86 | DYRK1A (0.51) | DHODHKDRBRAFEPHX2ALDH1A1 | |
| SCHEMBL23885462 | 0.82 | IGF2BP2 (0.45) | DHODHEPHX2ALDH1A1POLBGAA | |
| SCHEMBL30254114 | 0.82 | IGF2BP2 (0.45) | DHODHEPHX2ALDH1A1POLBGAA | |
| SCHEMBL7665668 | 0.81 | KCNQ3 (0.46) | DHODHKDRBRAFEPHX2ALDH1A1 | |
| SCHEMBL11726016 | 0.81 | RAB9A (0.41) | ALDH1A1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27054662 | 0.81 | IGF2BP2 (0.63) | DHODHEPHX2ALDH1A1POLBGAA | |
| SCHEMBL6676510 | 0.80 | IGF2BP2 (0.62) | DHODHPOLBGAARAB9ACYP1A2 | |
| SCHEMBL20565746 | 0.79 | KMT2A (0.53) | DHODHKDRBRAFALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| CN-110461831-B | Substituted indoline derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2022-11-01 | — | — | CN | disclosed |
| EP-3436436-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2022-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | IDO1, INMT, IRF3 | DHODH 53/4885KDR 494/4885BRAF 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.