Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2706925 | 1.00 | PARP1 (0.53) | PARP1UBE2TKCNH2OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL29475075 | 0.98 | PARP1 (0.52) | PARP1UBE2TKCNH2OPRM1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL30349640 | 0.91 | HPGDS (0.52) | PARP1UBE2TKCNH2OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL20293527 | 0.87 | GPR119 (0.54) | KCNH2HDAC2HDAC3HDAC1HDAC10 | |
| SCHEMBL1896186 | 0.86 | KCNH2 (0.53) | UBE2TKCNH2HDAC2HDAC3HRH3 | |
| SCHEMBL30289763 | 0.85 | UBE2T (0.71) | PARP1UBE2TOPRM1OPRK1HRH3 | |
| SCHEMBL29475033 | 0.85 | UBE2T (0.71) | PARP1UBE2TOPRM1OPRK1HRH3 | |
| SCHEMBL4935859 | 0.84 | MAPT (0.51) | UBE2TKCNH2HDAC2HDAC3HRH3 | |
| SCHEMBL7547417 | 0.84 | KCNH2 (0.52) | UBE2TKCNH2HDAC2HDAC3HRH3 | |
| SCHEMBL7550033 | 0.84 | KCNH2 (0.52) | UBE2TKCNH2HDAC2HDAC3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217355-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | Forkhead Biotherapeutics, inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066938-A1 | AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 | FORKHEAD BIOTHERAPEUTICS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |