Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.66 |
| ▸ | INSR | P06213 | 6/20 | 0.66 |
| ▸ | IGF1R | P08069 | 6/20 | 0.66 |
| ▸ | ULK1 | O75385 | 2/20 | 0.65 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.60 |
| ▸ | PLK1 | P53350 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29525992 | 0.86 | EGFR (0.70) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL15938455 | 0.81 | SRC (0.74) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL29045216 | 0.81 | EGFR (0.80) | ALKINSRIGF1REGFR | |
| SCHEMBL26970203 | 0.81 | MAP4K1 (0.76) | MAP4K1 | |
| SCHEMBL30689946 | 0.81 | MAP4K1 (0.76) | MAP4K1 | |
| SCHEMBL31174596 | 0.80 | ULK1 (0.87) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL23378028 | 0.79 | EGFR (0.81) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL17547465 | 0.79 | ULK1 (1.00) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL15938272 | 0.79 | MAPK8 (0.69) | MAPK8MAPK9MAPK10ALKINSR | |
| SCHEMBL30957977 | 0.78 | TTK (0.61) | ALKINSRIGF1RULK1CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240362-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | claimed |
| WO-2022098809-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | claimed |
| US-20230416225-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | MERCK SHARP & DOHME LLC (US) | 2023-12-28 | — | — | US | disclosed |
| EP-4240362-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098809-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416225-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | PDXK, PHKG1, PHKG2 | MAPK8 591/4885MAPK9 304/4885MAPK10 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.