Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | THRA | P10827 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29526743 | 0.96 | THRB (0.40) | THRBNPBWR1MCHR1THRALMNA | |
| SCHEMBL24600451 | 0.78 | THRB (0.31) | THRBNPBWR1MCHR1THRA | |
| SCHEMBL29526929 | 0.77 | NPBWR1 (0.39) | NPBWR1MCHR1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL24407930 | 0.76 | THRB (0.49) | THRBTHRA | |
| SCHEMBL30558175 | 0.73 | BMPR1B (0.32) | THRBNPBWR1 | |
| SCHEMBL26643264 | 0.73 | THRB (0.34) | THRBNPBWR1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL24407922 | 0.73 | THRB (0.48) | THRBTHRA | |
| SCHEMBL29527069 | 0.73 | THRB (0.37) | THRBNPBWR1MCHR1THRA | |
| SCHEMBL29527246 | 0.73 | THRB (0.37) | THRBNPBWR1MCHR1THRA | |
| SCHEMBL29622029 | 0.73 | THRB (0.37) | THRBNPBWR1MCHR1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |