Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30399128 | 0.93 | FYN (0.41) | EGFRSIRT6FLT3DYRK1AFYN | |
| SCHEMBL2946282 | 0.85 | CNR1 (0.36) | DHFRALK | |
| SCHEMBL2954051 | 0.84 | DHFR (0.44) | DHFR | |
| SCHEMBL2952950 | 0.82 | DHFR (0.43) | FLT3FYNDHFRALK | |
| SCHEMBL2953492 | 0.82 | TTK (0.47) | ALK | |
| SCHEMBL2951209 | 0.80 | KDM4E (0.42) | DHFRHRH4 | |
| SCHEMBL2950126 | 0.77 | TTK (0.42) | DHFR | |
| SCHEMBL2953119 | 0.76 | TTK (0.43) | EGFRFLT3ALK | |
| SCHEMBL2948890 | 0.75 | TTK (0.45) | DHFRALK | |
| SCHEMBL2952077 | 0.74 | INSR (0.42) | EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |