Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.73 |
| ▸ | MMP9 | P14780 | 6/20 | 0.73 |
| ▸ | BMP1 | P13497 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.60 |
| ▸ | MMP1 | P03956 | 2/20 | 0.59 |
| ▸ | MMP13 | P45452 | 2/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.57 |
| ▸ | CTSS | P25774 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323453 | 1.00 | MMP2 (0.73) | MMP2MMP9BMP1POLBADAMTS4 | |
| SCHEMBL6323452 | 1.00 | MMP2 (0.73) | MMP2MMP9BMP1POLBADAMTS4 | |
| SCHEMBL22234044 | 0.91 | MMP2 (0.86) | MMP2MMP9POLBADAMTS4MMP1 | |
| SCHEMBL6081543 | 0.91 | MMP2 (0.86) | MMP2MMP9POLBADAMTS4MMP1 | |
| SCHEMBL3718143 | 0.91 | MMP2 (0.86) | MMP2MMP9POLBADAMTS4MMP1 | |
| SCHEMBL27568136 | 0.91 | POLB (0.70) | MMP2MMP9POLBADAMTS4MMP1 | |
| SCHEMBL15943338 | 0.90 | MMP2 (0.75) | MMP2MMP9POLBADAMTS4MMP1 | |
| SCHEMBL20335146 | 0.88 | CTSL (0.67) | MMP2MMP9POLBADAMTS4ALDH1A1 | |
| SCHEMBL14534184 | 0.88 | CTSL (0.67) | MMP2MMP9POLBADAMTS4ALDH1A1 | |
| SCHEMBL20335144 | 0.88 | CTSL (0.67) | MMP2MMP9POLBADAMTS4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-10-22 | — | — | US | disclosed |
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, NFE2L2, HMOX1 | MMP2 2203/4885MMP9 2550/4885BMP1 4125/4885 |
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | KEAP1, NFE2L2, HMOX1 | MMP2 2203/4885MMP9 2550/4885BMP1 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.