Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29541893 | 0.83 | CNR2 (0.39) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL23538115 | 0.77 | POLB (0.52) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL23855046 | 0.76 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL23123661 | 0.75 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL25173418 | 0.73 | NPC1 (0.32) | ALDH1A1LMNACNR2SLC5A2NPC1 | |
| SCHEMBL15032969 | 0.72 | MAPT (0.37) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL14981605 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL30079489 | 0.72 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2KMT2AMEN1ERN1 | |
| SCHEMBL4718604 | 0.71 | TDP1 (0.37) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL15122465 | 0.71 | FGFR1 (0.48) | ALDH1A1SMN1; SMN2LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-10-22 | — | — | US | disclosed |
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, NFE2L2, HMOX1 | ALDH1A1 1856/4885SMN1; SMN2 1691/4885LMNA 4165/4885 |
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | KEAP1, NFE2L2, HMOX1 | ALDH1A1 1856/4885SMN1; SMN2 1691/4885LMNA 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.