Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109365 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL11453074 | 0.91 | — | — | |
| Formaldehyde SCHEMBL1558516 | 0.89 | CHRNA4 (0.41) | CHRNA4RAPGEF3RAPGEF4KDM4EALOX15 | |
| SCHEMBL11166684 | 0.73 | — | — | |
| SCHEMBL19913349 | 0.72 | RAPGEF3 (0.44) | CHRNA4RAPGEF3RAPGEF4KDM4ETSHR | |
| SCHEMBL2362735 | 0.72 | CHRNA4 (0.39) | CHRNA4RAPGEF3RAPGEF4KDM4EALDH1A1 | |
| SCHEMBL953695 | 0.72 | — | — | |
| SCHEMBL13799196 | 0.72 | CHRNA4 (0.39) | CHRNA4RAPGEF3RAPGEF4ALDH1A1SMN1; SMN2 | |
| SCHEMBL9709795 | 0.68 | CHRNA4 (0.38) | CHRNA4RAPGEF3RAPGEF4TSHRALDH1A1 | |
| SCHEMBL656888 | 0.68 | ATM (0.43) | CHRNA4KDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749980-B2 | Non-nucleotide compositions and method for treating pain | INSPIRE PHARMACEUTICALS, INC. (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1685135-B1 | TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION | INSPIRE PHARMACEUTICALS INC (US) | 2010-05-26 | — | — | EP | disclosed |
| US-7368438-B2 | Non-nucleotide compositions and method for inhibiting platelet aggregation | INSPIRE PHARMACEUTICALS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070123544-A1 | Non-nucleotide compositions and method for treating pain | INSPIRE PHARMACEUTICALS, INC. | 2007-05-31 | — | — | US | disclosed |
| EP-1685135-A1 | TETRAHYDRO-FURO¬3,4-D|DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION | Inspire Pharmaceuticals, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050159388-A1 | Non-nucleotide compositions and method for inhibiting platelet aggregation | INSPIRE PHARMACEUTICALS, INC. | 2005-07-21 | — | — | US | disclosed |
| WO-2005040174-A1 | TETRAHYDRO-FURO`3,4-D!DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-05-06 | — | — | WO | disclosed |
| WO-2005039590-A1 | NON-NUCLEOTIDE COMPOSITIONS AND METHOD FOR TREATING PAIN | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123544-A1 | Non-nucleotide compositions and method for treating pain | P2RX3, P2RX5, P2RX1 | CHRNA4 120/4885RAPGEF3 321/4885RAPGEF4 391/4885 |
| US-20050159388-A1 | Non-nucleotide compositions and method for inhibiting platelet aggregation | P2RY12, P2RY11, P2RY13 | CHRNA4 737/4885RAPGEF3 195/4885RAPGEF4 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.