Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | YES1 | P07947 | 1/20 | 0.30 |
| ▸ | FGR | P09769 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29548929 | 0.80 | DRD4 (0.39) | JAK2JAK1TYK2JAK3TNK2 | |
| SCHEMBL29548251 | 0.74 | JAK2 (0.36) | JAK2JAK1TYK2JAK3TNK2 | |
| SCHEMBL29548232 | 0.67 | EPHB3 (0.43) | TNK2MCHR1EPHB3 | |
| SCHEMBL29548844 | 0.67 | EPHB3 (0.43) | TNK2MCHR1EPHB3 | |
| SCHEMBL23425908 | 0.62 | EPHB3 (0.42) | EPHB3 | |
| SCHEMBL23089448 | 0.62 | EPHB3 (0.40) | NPBWR1EPHB3IRAK1 | |
| SCHEMBL29548354 | 0.62 | EPHB3 (0.43) | EPHB3 | |
| SCHEMBL659645 | 0.61 | ALOX5 (0.36) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL1806808 | 0.61 | — | — | |
| SCHEMBL31201601 | 0.60 | RET (0.45) | JAK2JAK1TYK2JAK3IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022070288-A1 | NITROGEN-CONTAINING BICYCLIC COMPOUND | 旭化成ファーマ株式会社 | 2022-04-07 | — | — | WO | disclosed |