Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552999 | 0.89 | TYK2 (0.57) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL28358963 | 0.87 | INSR (0.45) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL29922674 | 0.87 | INSR (0.45) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL29922581 | 0.86 | JAK2 (0.52) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28359240 | 0.86 | JAK2 (0.52) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28359065 | 0.80 | DGAT1 (0.49) | DGAT1KCNH2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29922819 | 0.80 | DGAT1 (0.49) | DGAT1KCNH2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29552105 | 0.80 | DGAT1 (0.49) | DGAT1KCNH2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15091106 | 0.76 | LMNA (0.41) | TYK2JAK2SYKMAPT | |
| SCHEMBL28359360 | 0.76 | KDM4E (0.41) | TYK2JAK2JAK1JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |