Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561470 | 0.87 | MEN1 (0.54) | KMT2AMEN1CES1CYP3A4CYP2D6 | |
| SCHEMBL29561679 | 0.87 | ACLY (0.57) | MAPTKMT2ALMNAMEN1CES1 | |
| SCHEMBL29561923 | 0.85 | CA1 (0.63) | MAPTALDH1A1KMT2AMEN1CES1 | |
| SCHEMBL29561320 | 0.85 | CA1 (0.50) | MAPTKMT2AMEN1SIRT6CES1 | |
| SCHEMBL29561400 | 0.83 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1CES1CYP3A4 | |
| SCHEMBL29561451 | 0.82 | FFAR4 (0.52) | MAPTALDH1A1KMT2AMEN1CES1 | |
| SCHEMBL29562488 | 0.81 | SIRT6 (0.71) | ALDH1A1LMNASIRT6CES1CYP3A4 | |
| SCHEMBL29561467 | 0.81 | PKM (0.55) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL29561532 | 0.80 | IDH1 (0.49) | MAPTALDH1A1LMNASIRT6CES1 | |
| SCHEMBL29561440 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1CES1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384694-B | SIRT6 small-molecule agonist and application thereof | 上海爱乐维生物科技有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-109384694-B | SIRT6 small-molecule agonist and application thereof | 上海爱乐维生物科技有限公司 | 2022-04-05 | — | — | CN | disclosed |