Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
| ▸ | CDK1 | P06493 | 8/20 | 0.36 |
| ▸ | CDK4 | P11802 | 8/20 | 0.36 |
| ▸ | CCND1 | P24385 | 8/20 | 0.36 |
| ▸ | CDK2 | P24941 | 8/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASK | O14936 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | CDK14 | O94921 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAK | P20794 | 1/20 | 0.34 |
| ▸ | CDK11B | P21127 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946285 | 0.90 | PDE4B (0.46) | PDE4BHSP90AA1HSP90AB1CDK9CCNT1 | |
| SCHEMBL2946224 | 0.85 | CDK1 (0.40) | CDK1CDK2HSP90AA1HSP90AB1CAMK2D | |
| SCHEMBL2948407 | 0.83 | PIK3CD (0.40) | TTK | |
| SCHEMBL2946341 | 0.81 | PIK3CD (0.39) | EGFRTTK | |
| SCHEMBL2950527 | 0.79 | ADORA2A (0.42) | CDK1CDK2HSP90AA1HSP90AB1 | |
| SCHEMBL2949173 | 0.75 | HSP90AA1 (0.47) | CDK1CDK2HSP90AA1HSP90AB1PI4KB | |
| SCHEMBL2956342 | 0.74 | PDE4B (0.42) | PDE4BEGFRCDK1CDK4CCND1 | |
| SCHEMBL2953676 | 0.74 | EGFR (0.39) | EGFRCDK4CCND1CDK9CCNT1 | |
| SCHEMBL17197373 | 0.73 | PDE4B (0.57) | PDE4BEGFRCDK9CCNT1TP53 | |
| SCHEMBL2953257 | 0.72 | CDK1 (0.42) | CDK1CDK2PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |