Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 6/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 5/20 | 0.38 |
| ▸ | CDK4 | P11802 | 5/20 | 0.38 |
| ▸ | CCND1 | P24385 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946279 | 0.90 | PDE4B (0.46) | PDE4BPDE7ACCNT1CDK9PDE7B | |
| SCHEMBL2946218 | 0.85 | CHEK1 (0.47) | PDE7ACARM1PDE7B | |
| SCHEMBL2948404 | 0.83 | CARM1 (0.39) | CCNT1CDK9CARM1 | |
| SCHEMBL2946339 | 0.81 | CARM1 (0.41) | CCNT1CDK9CARM1 | |
| SCHEMBL2950517 | 0.79 | ADORA2A (0.40) | PDE7ACARM1PDE7BPDE4D | |
| SCHEMBL2956345 | 0.74 | PDE4B (0.42) | PDE4BCCNT1CDK9CDK1CDK4 | |
| SCHEMBL2948866 | 0.73 | PARP1 (0.39) | CCNT1CDK9 | |
| SCHEMBL2947301 | 0.73 | PDE2A (0.48) | EGFR | |
| SCHEMBL17197373 | 0.73 | PDE4B (0.57) | PDE4BCCNT1CDK9EGFR | |
| SCHEMBL2953250 | 0.72 | CARM1 (0.40) | CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | claimed |