Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950808 | 0.87 | ESR2 (0.62) | DHODHESR2SMN1; SMN2CASP3SENP7 | |
| SCHEMBL26390953 | 0.81 | SMN1; SMN2 (0.59) | DHODHESR2SMN1; SMN2CASP3SENP7 | |
| SCHEMBL10725702 | 0.79 | MAPT (0.47) | DHODHESR2SMN1; SMN2CASP3SENP7 | |
| SCHEMBL26390969 | 0.79 | SMN1; SMN2 (0.56) | DHODHESR2SMN1; SMN2CASP3SENP7 | |
| SCHEMBL121400 | 0.78 | DHODH (0.94) | DHODHESR2SMN1; SMN2ESR1KDM4E | |
| SCHEMBL441801 | 0.78 | DHODH (0.68) | DHODHESR2SMN1; SMN2ESR1MAPT | |
| SCHEMBL17360636 | 0.78 | RAB9A (0.60) | DHODHESR2SMN1; SMN2ESR1MAPT | |
| SCHEMBL121632 | 0.77 | DHODH (0.70) | DHODHESR2SMN1; SMN2CASP3SENP7 | |
| SCHEMBL7356459 | 0.77 | ESR2 (0.42) | DHODHESR2ESR1MAPTPOLB | |
| SCHEMBL2959750 | 0.77 | DHODH (0.51) | DHODHSMN1; SMN2CASP3SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865634-B2 | 4-alkyl substituted pyridines as odiferous substances | SYMRISE AG (DE) | 2014-10-21 | — | — | US | disclosed |
| US-7781430-B2 | Benzoxazole carboxamides for treating CINV and IBS-D | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100130624-A1 | 4-ALKYL SUBSTITUTED PYRIDINES AS ODIFEROUS SUBSTANCES | SYMRISE GMBH & CO. KG (DE) | 2010-05-27 | — | — | US | disclosed |
| US-20080108609-A1 | Benzoxazole Carboxamides For Treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| US-7307094-B2 | Benzoxazole carboxamides for treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1853597-A1 | BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D | AMR Technology, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006089100-A1 | BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | AMR TECHNOLOGY, INC. (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130624-A1 | 4-ALKYL SUBSTITUTED PYRIDINES AS ODIFEROUS SUBSTANCES | CYP4A22, CYP4X1, CYP4B1 | DHODH 1426/4885ESR2 851/4885SMN1; SMN2 3664/4885 |
| US-20080108609-A1 | Benzoxazole Carboxamides For Treating CINV and IBS-D | HTR3E, BRS3, HTR3A | DHODH 2821/4885ESR2 628/4885SMN1; SMN2 4403/4885 |
| US-20060183769-A1 | Benzoxazole carboxamides for treating CINV and IBS-D | HTR3E, BRS3, HTR3A | DHODH 2821/4885ESR2 628/4885SMN1; SMN2 4403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.