Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735776 | 1.00 | ACHE (0.45) | ACHECES1KDM1AHDAC1HDAC6 | |
| SCHEMBL28786825 | 0.78 | LMNA (0.47) | KDM1AHDAC1HDAC6ARMAPT | |
| SCHEMBL29272276 | 0.76 | FTO (0.67) | ACHECES1MAPTKDM4EALDH1A1 | |
| SCHEMBL40395 | 0.76 | KDM4C (0.61) | KDM1AHDAC1HDAC6MAPTKDM4E | |
| SCHEMBL30527973 | 0.76 | KDM4C (0.61) | KDM1AHDAC1HDAC6MAPTKDM4E | |
| SCHEMBL24198783 | 0.76 | AR (0.45) | KDM1AHDAC1HDAC6ARALDH1A1 | |
| SCHEMBL27599068 | 0.75 | ACHE (0.46) | ACHECES1HDAC1HDAC6MLYCD | |
| SCHEMBL2430356 | 0.75 | KDM1A (0.44) | KDM1AHDAC1HDAC6ARMAPT | |
| SCHEMBL31026889 | 0.75 | PARP1 (0.48) | KDM1AHDAC1HDAC6MAPTKDM4E | |
| SCHEMBL1137138 | 0.75 | KDM1A (0.44) | KDM1AHDAC1HDAC6ARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |