Sugi Predict

Sugi Predict / Compounds / SCHEMBL2956996

SCHEMBL2956996

SCHEMBL2956996

O=C1CC(c2c[nH]c3ccccc23)=CN1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SIRT2 Q8IXJ6 2/20 0.50
▸ PRKD3 O94806 1/20 0.50
▸ CCNB2 O95067 1/20 0.50
▸ CCNE2 O96020 1/20 0.50
▸ ABL1 P00519 1/20 0.50
▸ PRKCG P05129 1/20 0.50
▸ PRKCB P05771 1/20 0.50
▸ CDK1 P06493 1/20 0.50
▸ PIM1 P11309 1/20 0.50
▸ CDK4 P11802 1/20 0.50
▸ CCNB1 P14635 1/20 0.50
▸ PRKCA P17252 1/20 0.50
▸ PRKACA P17612 1/20 0.50
▸ PRKACG P22612 1/20 0.50
▸ PRKACB P22694 1/20 0.50
▸ CCND1 P24385 1/20 0.50
▸ PRKCH P24723 1/20 0.50
▸ CCNE1 P24864 1/20 0.50
▸ CDK2 P24941 1/20 0.50
▸ PRKCI P41743 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1202543 0.72 IMPDH2 (0.63) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL9213561 0.71 DRD2 (0.59) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL2956991 0.71 SIRT2 (0.50) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL6858216 0.70 AXL (0.51) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL28773698 0.70 KDM4E (0.50) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL18392162 0.70 SIRT2 (0.61) SIRT2PRKD3CCNB2CCNE2ABL1
Ethylene SCHEMBL7259929 0.69 DRD2 (0.56) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL12456742 0.68 KDM4E (0.48) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL6795604 0.67 KDM4E (0.54) SIRT2PRKD3CCNB2CCNE2ABL1
SCHEMBL7197287 0.67 PRKCB (0.68) SIRT2PRKD3CCNB2CCNE2ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7855203-B2 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) 2010-12-21 — — US disclosed
US-20100240650-A1 SUBSTITUTED PYRROLINES AS KINASE INHIBITORS ZHANG HAN-CHENG 2010-09-23 — — US disclosed
US-7759380-B2 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2010-07-20 — — US disclosed
US-7608634-B2 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2009-10-27 — — US disclosed
US-7439363-B2 Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors JANSSEN PARMACEUTICA N.V. (BE) 2008-10-21 — — US disclosed
EP-1513520-B1 SUBSTITUTED PYRROLINES AS KINASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2008-09-24 — — EP disclosed
US-20080096949-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. 2008-04-24 — — US disclosed
US-7329657-B2 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2008-02-12 — — US disclosed
US-7304060-B2 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2007-12-04 — — US disclosed
US-20070213387-A1 Substituted pyrrolines as kinase inhibitors ZHANG HAN-CHENG 2007-09-13 — — US disclosed
US-20070213386-A1 Substituted pyrrolines as kinase inhibitors ZHANG HAN-CHENG 2007-09-13 — — US disclosed
US-7232906-B2 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA N.V. (BG) 2007-06-19 — — US disclosed
US-6987110-B2 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA N.V. (BE) 2006-01-17 — — US disclosed
US-6849643-B2 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2005-02-01 — — US disclosed
US-20050004202-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors ZHANG HAN-CHENG (US) 2005-01-06 — — US disclosed
US-20050004201-A1 Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors JANSSEN PHARMACEUTICA (BE) 2005-01-06 — — US disclosed
US-20040259928-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors ZHANG HAN-CHENG (US) 2004-12-23 — — US disclosed
US-20040059113-A1 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2004-03-25 — — US disclosed
US-20040054180-A1 Substituted pyrrolines as kinase inhibitors JANSSEN PHARMACEUTICA, NV (BE) 2004-03-18 — — US disclosed
US-20030055097-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors ORTHO-MCNEIL PHARMACEUTICAL, INC. 2003-03-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050004201-A1 Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors MAP2K2, MAP2K6, MAP3K2 SIRT2 1731/4885PRKD3 83/4885CCNB2 975/4885
US-20080096949-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors MAP2K2, MAP3K20, MAP2K3 SIRT2 2437/4885PRKD3 79/4885CCNB2 1167/4885
US-20100240650-A1 SUBSTITUTED PYRROLINES AS KINASE INHIBITORS PRKDC, MAP2K2, TTK SIRT2 3054/4885PRKD3 76/4885CCNB2 1756/4885
US-20040259928-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors MAP2K2, MAP3K20, MAP3K1 SIRT2 2372/4885PRKD3 94/4885CCNB2 1075/4885
US-20030055097-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors MAP2K2, MAP3K20, MAP3K1 SIRT2 2372/4885PRKD3 94/4885CCNB2 1075/4885
US-20050004202-A1 Indazolyl-substituted pyrroline compounds as kinase inhibitors MAP2K2, MAP3K20, MAP2K3 SIRT2 2437/4885PRKD3 79/4885CCNB2 1167/4885
US-20070213387-A1 Substituted pyrrolines as kinase inhibitors PRKDC, MAP2K2, TTK SIRT2 3054/4885PRKD3 76/4885CCNB2 1756/4885
US-20040054180-A1 Substituted pyrrolines as kinase inhibitors PRKDC, MAP2K2, TTK SIRT2 3054/4885PRKD3 76/4885CCNB2 1756/4885
US-20040059113-A1 Substituted pyrrolines as kinase inhibitors PRKDC, MAP2K2, TTK SIRT2 3054/4885PRKD3 76/4885CCNB2 1756/4885
US-20070213386-A1 Substituted pyrrolines as kinase inhibitors PRKDC, MAP2K2, TTK SIRT2 3054/4885PRKD3 76/4885CCNB2 1756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.