Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.35 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.35 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.35 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.35 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.35 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.35 |
| ▸ | AGPS | O00116 | 1/20 | 0.35 |
| ▸ | ACOT7 | O00154 | 1/20 | 0.35 |
| ▸ | MYO1F | O00160 | 1/20 | 0.35 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947675 | 0.90 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1LMNASMN1; SMN2ALPL | |
| SCHEMBL2959064 | 0.87 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1SMN1; SMN2EGFRIGF1R | |
| SCHEMBL2947361 | 0.83 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1LMNASMN1; SMN2ALPL | |
| SCHEMBL6198176 | 0.80 | HTR2A (0.53) | LMNAHDAC6HSD17B10ABL1RECQL | |
| SCHEMBL2953418 | 0.77 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1LMNASMN1; SMN2ALPL | |
| SCHEMBL2953052 | 0.76 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1LMNASMN1; SMN2ALPL | |
| SCHEMBL6591729 | 0.75 | DHODH (0.33) | ABL1AURKATTKSYKMAPK8 | |
| SCHEMBL13240036 | 0.74 | L3MBTL1 (0.68) | L3MBTL1ALDH1A1LMNASMN1; SMN2FYN | |
| SCHEMBL2953422 | 0.74 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1LMNASMN1; SMN2MAPK11 | |
| SCHEMBL2952931 | 0.74 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1LMNASMN1; SMN2ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754866-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090076254-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS INC. | 2009-03-19 | — | — | US | disclosed |
| US-7368539-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-06-02 | — | — | US | disclosed |
| US-6846919-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-25 | — | — | US | disclosed |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | BEHAN DOMINIC P (US) | 2003-12-04 | — | — | US | disclosed |
| US-20030153004-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. | 2003-08-14 | — | — | US | disclosed |
| US-6541209-B1 | Bioassay; identification of compounds as agonists; use in treatment of diseases and disorders that are related to 5-HT2A and or 5-HT2C serotonin receptors | ARENA PHARMACEUTICALS, INC. | 2003-04-01 | — | — | US | disclosed |
| US-6420541-B1 | MEMBRANE PROTEIN FOR USE IN TREATING PSYCHOLOGICAL, NERVOUS SYSTEM, EATING AND SEXUAL DISORDERS | ARENA PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6150393-A | N-(3-(4-BROMO-1-METHYLPYRAZOL-3-YL)PHENYL)(PHENYLMETHYLAMINO) -CARBOXAMIDE MODIFIER OF ACTIVITY OF THE SEROTONIN 5-HT 2A; CNS, GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | ARENA PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
| US-6107324-A | CONTROLLING SEROTONIN | ARENA PHARMACEUTICALS INC. (US) | 2000-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119182-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | HTR2A, HTR3B, HTR3A | L3MBTL1 4160/4885ALDH1A1 3499/4885LMNA 4266/4885 |
| US-20030153004-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | HTR2A, HTR3B, HTR6 | L3MBTL1 4246/4885ALDH1A1 3459/4885LMNA 4447/4885 |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | HTR2A, HTR5A, HTR1A | L3MBTL1 2801/4885ALDH1A1 3419/4885LMNA 4315/4885 |
| US-20090076254-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | HTR2A, HTR3B, HTR3A | L3MBTL1 4160/4885ALDH1A1 3499/4885LMNA 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.