Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717265 | 1.00 | PKM (0.55) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL12143424 | 0.88 | ALOX15 (0.57) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL24515328 | 0.86 | MAPT (0.47) | ALOX15KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL29845733 | 0.86 | MAPT (0.47) | ALOX15KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL12844576 | 0.85 | ALOX15 (0.53) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL27456981 | 0.84 | KMT2A (0.43) | PKML3MBTL1KDM4EMAPTALDH1A1 | |
| SCHEMBL12141938 | 0.83 | ALOX15 (0.51) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL12775442 | 0.83 | ALOX15 (0.51) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL22717301 | 0.82 | L3MBTL1 (0.51) | PKMALOX15L3MBTL1KDM4EGAA | |
| SCHEMBL22712785 | 0.82 | OPRK1 (0.44) | PKMMAPTDYRK1AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |