Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717354 | 1.00 | POLB (0.48) | POLBHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL17478919 | 0.88 | SMN1; SMN2 (0.48) | POLBHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL29845733 | 0.83 | MAPT (0.47) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL24515328 | 0.83 | MAPT (0.47) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL22121052 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL22717265 | 0.80 | PKM (0.55) | POLBHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL29574368 | 0.80 | PKM (0.55) | POLBHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL29846015 | 0.79 | ALOX15 (0.43) | POLBHTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL22717333 | 0.79 | CYP2C19 (0.49) | POLBKDM4ESMN1; SMN2ALDH1A1KMO | |
| SCHEMBL22717431 | 0.79 | POLB (0.44) | POLBKDM4ESMN1; SMN2ALDH1A1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |