Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.71 |
| ▸ | GCGR | P47871 | 8/20 | 0.71 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | RAF1 | P04049 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | BRAF | P15056 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469885 | 0.93 | MAPK14 (0.86) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8010209 | 0.91 | NOX1 (0.76) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9748575 | 0.91 | MAPK13 (0.83) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3956357 | 0.86 | MAPK13 (0.74) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL31061110 | 0.85 | CYP19A1 (1.00) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL252964 | 0.85 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL15401173 | 0.85 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL2127491 | 0.85 | MAPK13 (0.85) | CYP19A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9619859 | 0.85 | MAPK13 (0.85) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL27233089 | 0.85 | MAPK13 (0.85) | CYP19A1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107624-A1 | METHODS OF OVERCOMING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. (US) | 2024-05-23 | — | — | WO | claimed |
| US-20240011101-A1 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. | 2024-01-11 | — | — | US | claimed |
| EP-4256344-A2 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | Shattuck Labs, Inc. (US) | 2023-10-11 | — | — | EP | claimed |
| WO-2022120187-A2 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. (US) | 2022-06-09 | — | — | WO | claimed |
| WO-2024107624-A1 | METHODS OF OVERCOMING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |
| US-20240016892-A1 | METHODS OF TREATING CANCER USING TIGIT-AND LIGHT-BASED CHIMERIC PROTEINS | SHATTUCK LABS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240011101-A1 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. | 2024-01-11 | — | — | US | disclosed |
| EP-4255464-A1 | METHODS OF TREATING CANCER USING TIGIT-AND LIGHT-BASED CHIMERIC PROTEINS | Shattuck Labs, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-4256344-A2 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | Shattuck Labs, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| CN-116829953-A | Methods of determining resistance to checkpoint inhibitor therapy | 沙塔克实验室有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2022120187-A2 | METHOD OF DETERMINING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES | SHATTUCK LABS, INC. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120191-A1 | METHODS OF TREATING CANCER USING TIGIT-AND LIGHT-BASED CHIMERIC PROTEINS | SHATTUCK LABS, INC. (US) | 2022-06-09 | — | — | WO | disclosed |