Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 13/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31133393 | 1.00 | GRM4 (0.49) | GRM4KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL3219167 | 0.84 | PARP1 (0.45) | GRM4KDM4EITKMAPK10HSD17B10 | |
| SCHEMBL29455053 | 0.84 | PARP1 (0.45) | GRM4KDM4EITKMAPK10HSD17B10 | |
| SCHEMBL16517165 | 0.80 | KDM4E (0.60) | GRM4KDM4EL3MBTL1FLT3 | |
| SCHEMBL23495801 | 0.79 | KDM4E (0.41) | GRM4KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL29600787 | 0.79 | KDM4E (0.41) | GRM4KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL16538721 | 0.77 | KDM4E (0.63) | GRM4KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL2966912 | 0.77 | COMT (0.49) | GRM4KDM4EMAPTALDH1A1ITK | |
| SCHEMBL5316095 | 0.77 | ALDH1A1 (0.46) | GRM4KDM4EALDH1A1 | |
| Urea SCHEMBL28025849 | 0.74 | ITK (0.44) | GRM4KDM4ECYP3A4ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577243-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-17 | — | — | US | disclosed |
| EP-3856178-B1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-11 | — | — | EP | disclosed |
| CN-119661525-A | Method for constructing pyrazolo [3,4-b ] pyridine by dehydrocyclization of 5-aminopyrazole and allyl alcohol | 润华(江苏)新材料有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-114981257-B | Substituted pyrazolopiperidine carboxylic acids | 拜耳公司 | 2024-07-05 | — | — | CN | disclosed |
| US-20240209001-A1 | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS | Chiesi Farmaceutici S.p. A. (IT) | 2024-06-27 | — | — | US | disclosed |
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| CN-116897152-A | Substituted pyrazolylpiperidine carboxylic acids | 拜耳公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116829545-A | Substituted pyrazolylpiperidine carboxylic acids | 拜耳公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116710439-A | Substituted pyrazolopiperidine carboxylic acids | 拜耳公司 | 2023-09-05 | — | — | CN | disclosed |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-11 | — | — | US | disclosed |
| EP-1814883-A1 | BICYCLIC INHIBITORS OR RHO KINASE | Vertex Pharmaceuticals Incorporated (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20060122185-A1 | Bicyclic inhibitors of Rho kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2006-06-08 | — | — | US | disclosed |
| WO-2006058120-A1 | BICYCLIC INHIBITORS OR RHO KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-06-01 | — | — | WO | disclosed |
| US-5098899-A | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites | TRUSTEES OF BOSTON UNIVERSITY (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0361382-A3 | ANTIEPILEPTIC PYRAZOLOPYRIDINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4916140-A | CALCIUM CHANNEL BLOCKERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0361382-A2 | Antiepileptic pyrazolopyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-04 | — | — | EP | disclosed |
| US-3879512-A | Anti-anxiety combination and method of use | SQUIBB & SONS INC | 1975-04-22 | — | — | US | disclosed |
| US-3862947-A | Intermediate for production of alkoxy derivatives of pyrazolopyridine carboxylic acids and esters | SQUIBB & SONS INC | 1975-01-28 | — | — | US | disclosed |
| US-3761487-A | HYDRAZINES OF PYRAZOLOPYRIDINE CARBOXYLIC ACIDS AND ESTERS | SQUIBB & SONS INC | 1973-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122185-A1 | Bicyclic inhibitors of Rho kinase | ROCK1, ROCK2, RHOA | GRM4 4147/4885KDM4E 1635/4885MAPT 719/4885 |
| US-12577243-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, FAAH | GRM4 203/4885KDM4E 3565/4885MAPT 3782/4885 |
| US-20230145249-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | GRM4 127/4885KDM4E 2437/4885MAPT 2516/4885 |
| US-20240209001-A1 | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS | TYK2, JAK3, JAK1 | GRM4 3199/4885KDM4E 1093/4885MAPT 3444/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | GRM4 127/4885KDM4E 2437/4885MAPT 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.