Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28921115 | 1.00 | GPR84 (0.55) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Fumaric Acid SCHEMBL10835017 | 0.98 | GPR84 (0.52) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Fumaric Acid SCHEMBL28962418 | 0.98 | GPR84 (0.52) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Maleic Acid SCHEMBL29780364 | 0.98 | GPR84 (0.52) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Maleic Acid SCHEMBL28887158 | 0.98 | GPR84 (0.52) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Fumaric Acid SCHEMBL28760858 | 0.98 | GPR84 (0.52) | GPR84FFAR1HCAR2FFAR4ACHE | |
| Maleic Acid SCHEMBL28046211 | 0.91 | ACHE (0.58) | GPR84FFAR1HCAR2ACHEBACE1 | |
| Adipic Acid SCHEMBL28760830 | 0.89 | FFAR4 (0.62) | GPR84FFAR1FFAR4PPARD | |
| Bicarbonate SCHEMBL28559081 | 0.87 | GPR84 (0.64) | GPR84FFAR1FFAR4MAPTLCK | |
| Acrylic Acid SCHEMBL11869433 | 0.86 | GPR84 (0.53) | GPR84FFAR1FFAR4MAPTLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114524926-A | Biodegradable antibacterial cationic polyester and preparation method and application thereof | 中国科学院化学研究所 | 2022-05-24 | — | — | CN | disclosed |