Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28887158 | 0.93 | GPR84 (0.52) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Fumaric Acid SCHEMBL28962418 | 0.93 | GPR84 (0.52) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Fumaric Acid SCHEMBL10835017 | 0.93 | GPR84 (0.52) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Fumaric Acid SCHEMBL28760858 | 0.93 | GPR84 (0.52) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Maleic Acid SCHEMBL29780364 | 0.93 | GPR84 (0.52) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Maleic Acid SCHEMBL28921115 | 0.91 | GPR84 (0.55) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Maleic Acid SCHEMBL29613019 | 0.91 | GPR84 (0.55) | ACHEBACE1HCAR2GPR84FFAR1 | |
| Fumaric Acid SCHEMBL5336280 | 0.86 | ACHE (0.47) | ACHEBACE1HCAR2TSHRTP53 | |
| Maleic Acid SCHEMBL22551491 | 0.86 | ACHE (0.47) | ACHEBACE1HCAR2TSHRTP53 | |
| Maleic Acid SCHEMBL30662801 | 0.86 | ACHE (0.47) | ACHEBACE1HCAR2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103804660-B | A kind of unsaturated aliphatic-polylactic-acid block copolymer and preparation method thereof | CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN) | 2016-02-03 | — | — | CN | disclosed |