Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 5/20 | 0.50 |
| ▸ | USP2 | O75604 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850007 | 0.83 | MAOA (0.56) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| SCHEMBL2229694 | 0.74 | ADORA2A (0.50) | MAOAMAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL4958351 | 0.74 | MAPT (0.34) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| Anthrarufin SCHEMBL187843 | 0.72 | MAOA (1.00) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| Anthrarufin SCHEMBL29874705 | 0.72 | MAOA (1.00) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| SCHEMBL875843 | 0.72 | MAPT (0.86) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| Anthrarufin SCHEMBL29363946 | 0.72 | MAOA (1.00) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| SCHEMBL112133 | 0.70 | MEN1 (0.50) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| SCHEMBL29714477 | 0.70 | MEN1 (0.50) | MAOAMAPTALDH1A1TDP1ALOX15 | |
| Danthron SCHEMBL29356886 | 0.70 | MAPT (1.00) | MAOAMAPTALDH1A1TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655301-B1 | CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON | ZHILOV VALERY KHAZHMURATOVICH (RU) | 2015-03-11 | — | — | EP | claimed |
| US-8592421-B2 | Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon | Zhilov, Valery Khazhmuratovich (RU) | 2013-11-26 | — | — | US | claimed |
| EP-2074998-B1 | Use of cyclic bioisosteres of purine system derivatives for the treatment of diseases caused by disorders of nitrergic and dopaminergic systems | ZHILOV VALERY KHAZHMURATOVICH (RU) | 2013-10-16 | — | — | EP | claimed |
| US-7776833-B2 | Use of cyclic bioisosters of purine system derivatives for treating diseases produced by disorders of niterergic and dopaminergic systems | Zhilov, Valery Khazhmuratovich (RU) | 2010-08-17 | — | — | US | claimed |
| EP-2074998-A2 | Use of cyclic bioisosteres of purine system derivatives for the treatment of diseases caused by disorders of nitrergic and dopaminergic systems | Zhilov, Valery Khazhmuratovich (RU) | 2009-07-01 | — | — | EP | claimed |
| US-20080194501-A1 | Cyclic Bioisosters of Derivatives of a Purine System and Pharmaceutical Composition Based Thereon | ZHILOV, VALERY KHAZHMURATOVICH (RU) | 2008-08-14 | — | — | US | claimed |
| US-20070135636-A1 | Use of cyclic bioisosters of purine system derivatives for treating diseases produced by disorders of niterergic and dopaminergic systems | VALERY KHAZHMURATOVICH ZHILOV (RU) | 2007-06-14 | — | — | US | claimed |
| EP-1655301-A1 | CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON | Zhilov, Valery Khazhmuratovich (RU) | 2006-05-10 | — | — | EP | claimed |
| EP-1655028-A2 | USE OF CYCLIC BIOISOSTERES OF PURINE SYSTEM DERIVATIVES FOR THE TREATMENT OF DISEASES CAUSED BY DISORDERS OF NITRERGIC AND DOPAMINERGIC SYSTEMS | Zhilov, Valery Khazhmuratovich (RU) | 2006-05-10 | — | — | EP | claimed |
| EP-0675968-B1 | ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS | LUMIGEN INC (US) | 2002-03-13 | — | — | EP | claimed |
| EP-0938677-A4 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN INC (US) | 2000-09-27 | — | — | EP | claimed |
| EP-0938677-A1 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN, INC. (US) | 1999-09-01 | — | — | EP | claimed |
| US-5843666-A | Chemiluminescent detection methods using dual enzyer-labeled binding partners | LUMIGEN, INC. (US) | 1998-12-01 | — | — | US | claimed |
| WO-1998021586-A1 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN, INC. (US) | 1998-05-22 | — | — | WO | claimed |
| EP-0675968-A4 | ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS. | LUMIGEN INC (US) | 1997-11-26 | — | — | EP | claimed |
| US-5601977-A | GENERATING CHEMILUMINESCENCE FROM OXIDATION OF CYCLIC DIACYLHYDRAZIDE DERIVATIVE BY ACTION OF PEROXIDASE ENZYME, A PEROXIDE OXIDIZER AND ENHANCER | LUMIGEN, INC. (US) | 1997-02-11 | — | — | US | claimed |
| EP-0675968-A1 | ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS | LUMIGEN, INC. (US) | 1995-10-11 | — | — | EP | claimed |
| WO-1994014979-A1 | ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS | LUMIGEN, INC. (US) | 1994-07-07 | — | — | WO | claimed |
| EP-1655301-B1 | CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON | ZHILOV VALERY KHAZHMURATOVICH (RU) | 2015-03-11 | — | — | EP | disclosed |
| US-3933488-A | CHEMILUMINESCENCE | FUJI PHOTO FILM CO., LTD. (JA) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135636-A1 | Use of cyclic bioisosters of purine system derivatives for treating diseases produced by disorders of niterergic and dopaminergic systems | ADORA2A, ADORA3, ADORA1 | MAOA 51/4885MAPT 1864/4885ALDH1A1 1009/4885 |
| US-20080194501-A1 | Cyclic Bioisosters of Derivatives of a Purine System and Pharmaceutical Composition Based Thereon | ADORA3, ADORA2A, ADORA2B | MAOA 1442/4885MAPT 4848/4885ALDH1A1 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.