Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | NEK2 | P51955 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990307 | 0.78 | CHEK1 (0.73) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29919884 | 0.78 | CHEK1 (0.73) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL904667 | 0.74 | CYP1A2 (0.56) | EP300KAT8MAPTLMNAHTT | |
| SCHEMBL16668583 | 0.69 | PKM (0.47) | EP300KAT8LMNAKMT2AIDO1 | |
| SCHEMBL15901381 | 0.69 | GPR84 (0.39) | EP300KAT8MEN1KMT2AIDO1 | |
| SCHEMBL8720110 | 0.69 | CHEK1 (0.65) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL1755244 | 0.69 | CYP1A2 (0.62) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL29862285 | 0.69 | CYP1A2 (0.62) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL18346844 | 0.68 | LMNA (0.45) | CHEK1NEK2LIMK1DYRK1ACLK4 | |
| SCHEMBL69495 | 0.68 | TYMS (0.46) | CHEK1NEK2LIMK1DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767817-B2 | Water soluble boronic acid fluorescent reporter compounds and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-03 | — | — | US | disclosed |
| US-20070274922-A1 | Water Soluble Boronic Acid Fluorescent Reporter Compounds and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-29 | — | — | US | disclosed |
| WO-2005024416-A1 | WATER SOLUBLE BORONIC ACID FLUORESCENT REPORTER COMPOUNDS AND METHODS OF USE THEREOF | WANG BINGHE (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070274922-A1 | Water Soluble Boronic Acid Fluorescent Reporter Compounds and Methods of Use Thereof | GUSB, BLVRB, BCL6 | CHEK1 3082/4885NEK2 2822/4885LIMK1 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.