Almplyaci

Almplyaci

SCHEMBL29615870

CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ NTSR1 P30989 20/20 0.57
▸ NTSR2 O95665 17/20 0.57
▸ SORT1 Q99523 15/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29737347 0.85 NTSR2 (0.68) NTSR1NTSR2SORT1
SCHEMBL31717953 0.84 NTSR1 (0.56) NTSR1NTSR2SORT1
SCHEMBL30437023 0.83 CALCR (0.65) —
SCHEMBL31694383 0.83 NTSR1 (0.68) NTSR1NTSR2SORT1
Reltecimod SCHEMBL29430066 0.83 CXCL8 (0.53) NTSR1NTSR2
SCHEMBL29769336 0.83 NTSR1 (0.59) NTSR1NTSR2SORT1
SCHEMBL29802489 0.82 SLC6A2 (0.60) NTSR1NTSR2SORT1
SCHEMBL31679338 0.81 SLC6A2 (0.60) NTSR1NTSR2SORT1
SCHEMBL31378961 0.81 NTSR1 (0.54) NTSR1NTSR2SORT1
SCHEMBL30881987 0.81 REN (0.59) NTSR1NTSR2SORT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702461-B2 T-cell modulatory multimeric polypeptides comprising reduced-affinity immunomodulatory polypeptides CUE BIOPHARMA, INC. (US) 2023-07-18 — — US claimed
US-12528839-B2 Conjugated virus-like particles and uses thereof as anti-tumor immune redirectors VERIMMUNE, INC. (US) 2026-01-20 — — US disclosed
US-20250223320-A1 HEPATITIS B VACCINES AND USES OF THE SAME PRECIGEN, INC. (US) 2025-07-10 — — US disclosed
US-12344637-B2 Virus-inspired compositions and methods of redirecting preexisting immune responses using the same for treatment of cancer VERIMMUNE INC. 2025-07-01 — — US disclosed
US-12234261-B2 Hepatitis B vaccines and uses of the same PRECIGEN, INC. (US) 2025-02-25 — — US disclosed
US-20240409606-A1 T-Cell Modulatory Multimeric Polypeptide with Conjugation Sites and Methods of Use Thereof CUE BIOPHARMA INC (US) 2024-12-12 — — US disclosed
US-20240390473-A1 CHIMERIC VIRUS-LIKE PARTICLES AND USES THEREOF AS ANTIGEN-SPECIFIC REDIRECTORS OF IMMUNE RESPONSES VERIMMUNE INC. 2024-11-28 — — US disclosed
US-20240294577-A1 VIRUS-INSPIRED COMPOSITIONS AND METHODS OF REDIRECTING PREEXISTING IMMUNE RESPONSES USING THE SAME FOR TREATMENT OF CANCER VERIMMUNE INC. 2024-09-05 — — US disclosed
US-12006348-B2 T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof CUE BIOPHARMA, INC. (US) 2024-06-11 — — US disclosed
US-11944677-B2 Chimeric virus-like particles and uses thereof as antigen-specific redirectors of immune responses VERIMMUNE INC. (US) 2024-04-02 — — US disclosed
US-20230279076-A1 T-Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof CUE BIOPHARMA, INC. 2023-09-07 — — US disclosed
US-11702461-B2 T-cell modulatory multimeric polypeptides comprising reduced-affinity immunomodulatory polypeptides CUE BIOPHARMA, INC. (US) 2023-07-18 — — US disclosed
US-20230201335-A1 Antigen Presenting Polypeptide Complexes and Methods of Use Thereof CUE BIOPHARMA, INC. 2023-06-29 — — US disclosed
EP-4182465-A2 T-CELL MODULATORY POLYPEPTIDES WITH CONJUGATION SITES AND METHODS OF USE THEREOF Cue Biopharma, Inc. (US) 2023-05-24 — — EP disclosed
EP-4157349-A1 ANTIGEN PRESENTING POLYPEPTIDE COMPLEXES AND METHODS OF USE THEREOF Cue Biopharma, Inc. (US) 2023-04-05 — — EP disclosed
US-11608362-B2 Hepatitis B vaccines and uses of the same PRECIGEN, INC. (US) 2023-03-21 — — US disclosed
US-11560408-B2 Conjugated virus-like particles and uses thereof as anti-tumor immune redirectors VERIMMUNE INC. (US) 2023-01-24 — — US disclosed
US-20220226460-A1 CHIMERIC VIRUS-LIKE PARTICLES AND USES THEREOF AS ANTIGEN-SPECIFIC REDIRECTORS OF IMMUNE RESPONSES VERIMMUNE INC. 2022-07-21 — — US disclosed
US-20220135624-A1 VIRUS-INSPIRED COMPOSITIONS AND METHODS OF REDIRECTING PREEXISTING IMMUNE RESPONSES USING THE SAME FOR TREATMENT OF CANCER VERIMMUNE INC. 2022-05-05 — — US disclosed
US-11285203-B2 Chimeric virus-like particles and uses thereof as antigen-specific redirectors of immune responses VERIMMUNE INC. (US) 2022-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12006348-B2 T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof IL2, CD4, HLA-DRB1 NTSR1 956/4885NTSR2 404/4885SORT1 758/4885
US-12528839-B2 Conjugated virus-like particles and uses thereof as anti-tumor immune redirectors KLK3, KLKB1, CTSV NTSR1 1181/4885NTSR2 2352/4885SORT1 1501/4885
US-20240409606-A1 T-Cell Modulatory Multimeric Polypeptide with Conjugation Sites and Methods of Use Thereof IL2, CD4, HLA-DRB1 NTSR1 956/4885NTSR2 404/4885SORT1 758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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