Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2960273 | 0.84 | PREP (0.57) | FKBP1A | |
| SCHEMBL26818731 | 0.83 | PDK1 (0.46) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29959741 | 0.83 | PDK1 (0.46) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL25772046 | 0.83 | PDK1 (0.46) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29132380 | 0.83 | SMN1; SMN2 (0.54) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL8340452 | 0.83 | PRSS1 (0.52) | TMEM97SIGMAR1PARP1SMN1; SMN2NPC1 | |
| SCHEMBL8346225 | 0.83 | PRSS1 (0.52) | TMEM97SIGMAR1PARP1SMN1; SMN2NPC1 | |
| SCHEMBL13660819 | 0.83 | HRH3 (0.61) | HRH3OPRK1 | |
| SCHEMBL31040355 | 0.82 | GPR119 (0.54) | TMEM97SIGMAR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18921646 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767681-B2 | 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-08-03 | — | — | US | disclosed |
| US-20070179126-A1 | 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-08-02 | — | — | US | disclosed |
| CN-101001847-A | 2-Urea-4-phenylthiazole derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS (FR) | 2007-07-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179126-A1 | 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | UGT2B7, PKD2, CYP2C19 | TMEM97 3672/4885SIGMAR1 2247/4885PARP1 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.