Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.46 |
| ▸ | LIPC | P11150 | 2/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL23149170 | 1.00 | LPL (0.46) | LPLLIPCLIPGSLC6A4HTR2C | |
| SCHEMBL21618376 | 0.91 | SLC6A4 (0.42) | LPLLIPCLIPGSLC6A4HTR2C | |
| Trifluoroacetic Acid SCHEMBL30945211 | 0.76 | IDO1 (0.47) | LPLLIPCLIPGSLC6A4HTR2C | |
| Trifluoroacetic Acid SCHEMBL23152297 | 0.76 | IDO1 (0.47) | LIPGSLC6A4HTR2CHTR2BDAO | |
| Trifluoroacetic Acid SCHEMBL25325427 | 0.75 | SLC6A4 (0.45) | SLC6A4HTR2CHTR2BKMT2APPARD | |
| Trifluoroacetic Acid SCHEMBL23150549 | 0.75 | MGLL (0.49) | SLC6A4HTR2CHTR2BMRGPRX4DAO | |
| Trifluoroacetic Acid SCHEMBL22462993 | 0.74 | CHRNA7 (0.48) | MRGPRX4SCN9A | |
| Trifluoroacetic Acid SCHEMBL31411020 | 0.73 | ALOX5AP (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL26620566 | 0.72 | LIPG (0.49) | LIPGSCN9A | |
| Hydrochloric Acid SCHEMBL21640519 | 0.70 | KDM1A (0.44) | HTR2CKMT2AKDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034538-A1 | NEW HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-08-03 | — | — | EP | disclosed |
| CN-114401968-A | Novel heterocyclic monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2022-04-26 | — | — | CN | disclosed |