Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.32 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PRF1 | P14222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618323 | 0.88 | PNMT (0.44) | PNMTPTGS2P2RY6CHRNA1CHRNG | |
| SCHEMBL24517521 | 0.76 | ADRA2A (0.41) | PNMTP2RY6 | |
| SCHEMBL23481105 | 0.76 | PNMT (0.41) | PNMTCHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL6808079 | 0.73 | SLC6A4 (0.40) | PNMTCHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL14199799 | 0.72 | FADS1 (0.40) | DRD2DRD3TRPM5TRPM4 | |
| SCHEMBL22043585 | 0.72 | FADS1 (0.40) | DRD2DRD3TRPM5TRPM4 | |
| SCHEMBL1686 | 0.72 | FADS1 (0.40) | DRD2DRD3TRPM5TRPM4 | |
| SCHEMBL8899288 | 0.70 | CHRNA1 (0.35) | PNMTCHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL8896169 | 0.70 | KDM4E (0.36) | PNMTCHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL6810997 | 0.68 | PPARA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |