Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618378 | 0.85 | KCNK3 (0.48) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29618337 | 0.83 | KCNK3 (0.48) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5054886 | 0.74 | KDM4E (0.45) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7912928 | 0.73 | KDM4E (0.44) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29618311 | 0.71 | SPR (0.45) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL7916724 | 0.71 | ADRA2A (0.41) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24517541 | 0.69 | SCN10A (0.55) | — | |
| SCHEMBL22792003 | 0.69 | SMN1; SMN2 (0.63) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29618400 | 0.69 | SMN1; SMN2 (0.48) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5060694 | 0.69 | ADRA2A (0.47) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |