Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 8/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | S100B | P04271 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24374911 | 1.00 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1PSMD14CYP3A4TSHR | |
| SCHEMBL6653846 | 0.83 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1PSMD14CYP3A4TSHR | |
| SCHEMBL13740899 | 0.83 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2793198 | 0.81 | BRAF (0.39) | CYP3A4NCF1NOS3NOS2MTOR | |
| SCHEMBL30585768 | 0.81 | BRAF (0.39) | CYP3A4NCF1NOS3NOS2MTOR | |
| SCHEMBL23107378 | 0.79 | HSD17B10 (0.36) | ALDH1A1L3MBTL1PSMD14CYP3A4TSHR | |
| SCHEMBL10580706 | 0.78 | ALDH1A1 (0.64) | ALDH1A1L3MBTL1PSMD14CYP3A4TSHR | |
| SCHEMBL30116117 | 0.76 | MAPT (0.38) | ALDH1A1L3MBTL1MAPK1RECQL | |
| SCHEMBL12927172 | 0.76 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1PSMD14CYP3A4TSHR | |
| SCHEMBL3822535 | 0.75 | OXTR (0.43) | ALDH1A1MTORPIK3CAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12070457-B2 | Substituted pyridines, pyridazines, pyrimidines, and 1,2,3-triazines as bruton's tyrosine kinase inhibitors | HUTCHISON MEDIPHARMA LIMITED (CN) | 2024-08-27 | — | — | US | disclosed |
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-02-09 | — | — | US | disclosed |
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A4, CYP4B1, CYP3A5 | ALDH1A1 1919/4885L3MBTL1 4630/4885PSMD14 4368/4885 |
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A43, CYP3A5, CYP11B2 | ALDH1A1 425/4885L3MBTL1 4863/4885PSMD14 4531/4885 |
| US-12070457-B2 | Substituted pyridines, pyridazines, pyrimidines, and 1,2,3-triazines as bruton's tyrosine kinase inhibitors | ABL1, BTK, ABL2 | ALDH1A1 3913/4885L3MBTL1 4115/4885PSMD14 3889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.