Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29620364 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL24375459 | 0.81 | TNKS2 (0.34) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29620360 | 0.76 | THRA (0.42) | ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL26027147 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL27089947 | 0.76 | PARP1 (0.45) | ALDH1A1MEN1KMT2AHSD17B10GPR35 | |
| SCHEMBL29620356 | 0.74 | RARG (0.46) | ALDH1A1MEN1KMT2AHSD17B10LMNA | |
| SCHEMBL26026549 | 0.74 | RARG (0.46) | ALDH1A1MEN1KMT2AHSD17B10LMNA | |
| SCHEMBL26026709 | 0.72 | RARG (0.46) | ALDH1A1MEN1KMT2AGRIN2DGRIN3B | |
| SCHEMBL26027642 | 0.70 | TNKS (0.43) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL26027474 | 0.70 | ALDH1A1 (0.33) | ALDH1A1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232436-A1 | PROCESS FOR THE PREPARATION OF 6-(4-NITRO-PHENOXY)-2H-PYRIDAZIN-3-ONE AND 6-(4-AMINO-PHENOXY)-2H-PYRIDAZIN-3-ONE DERIVATIVES AS INTERMEDIATES OF THYROID HORMONE ANALOGUES | Madrigal Pharmaceuticals, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116406356-A | Process for the preparation of 6- (4-nitro-phenoxy) -2H-pyridazin-3-one and 6- (4-amino-phenoxy) -2H-pyridazin-3-one derivatives as intermediates for thyroid hormone analogues | 马德里加尔制药公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2022087141-A1 | PROCESS FOR THE PREPARATION OF 6-(4-NITRO-PHENOXY)-2H-PYRIDAZIN-3-ONE AND 6-(4-AMINO-PHENOXY)-2H-PYRIDAZIN-3-ONE DERIVATIVES AS INTERMEDIATES OF THYROID HORMONE ANALOGUES | MADRIGAL PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |