Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 16/20 | 0.42 |
| ▸ | THRB | P10828 | 16/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24375474 | 0.84 | THRA (0.61) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL29029719 | 0.81 | THRB (0.40) | THRATHRBALDH1A1CYP2C9UGT1A1 | |
| SCHEMBL24375458 | 0.81 | THRB (0.46) | THRATHRBCYP2C9UGT1A1ABCG2 | |
| SCHEMBL29620358 | 0.79 | MAPT (0.40) | THRATHRBMEN1KMT2A | |
| SCHEMBL29620364 | 0.79 | ALDH1A1 (0.39) | THRATHRBALDH1A1MEN1KMT2A | |
| SCHEMBL29620357 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL29527110 | 0.75 | MEN1 (0.45) | ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL26027147 | 0.74 | ALDH1A1 (0.39) | THRATHRBALDH1A1MEN1KMT2A | |
| SCHEMBL27089947 | 0.73 | PARP1 (0.45) | ALDH1A1MEN1KMT2A | |
| SCHEMBL23691262 | 0.73 | MAPT (0.41) | ALDH1A1MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232436-A1 | PROCESS FOR THE PREPARATION OF 6-(4-NITRO-PHENOXY)-2H-PYRIDAZIN-3-ONE AND 6-(4-AMINO-PHENOXY)-2H-PYRIDAZIN-3-ONE DERIVATIVES AS INTERMEDIATES OF THYROID HORMONE ANALOGUES | Madrigal Pharmaceuticals, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116406356-A | Process for the preparation of 6- (4-nitro-phenoxy) -2H-pyridazin-3-one and 6- (4-amino-phenoxy) -2H-pyridazin-3-one derivatives as intermediates for thyroid hormone analogues | 马德里加尔制药公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2022087141-A1 | PROCESS FOR THE PREPARATION OF 6-(4-NITRO-PHENOXY)-2H-PYRIDAZIN-3-ONE AND 6-(4-AMINO-PHENOXY)-2H-PYRIDAZIN-3-ONE DERIVATIVES AS INTERMEDIATES OF THYROID HORMONE ANALOGUES | MADRIGAL PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |