SCHEMBL2962049

SCHEMBL2962049

CCC(C)Nc1c(C)cc(Cc2cc(C)c(N)c(C)c2)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
CYP3A4 P08684 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
TP53 P04637 2/20 0.38
TSHR P16473 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
HSP90AA1 P07900 1/20 0.38
THRB P10828 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HIF1A Q16665 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HMGB1 P09429 1/20 0.32
CXCL12 P48061 1/20 0.32
POLB P06746 1/20 0.31
HCAR3 P49019 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2956305 0.91 L3MBTL1 (0.46) ALDH1A1CYP3A4L3MBTL1CYP1A2CYP2C9
SCHEMBL2970690 0.77 ALDH1A1 (0.39) ALDH1A1CYP3A4L3MBTL1CYP1A2CYP2C9
SCHEMBL307367 0.77 ALDH1A1 (0.55) ALDH1A1CYP3A4CYP1A2TP53TSHR
SCHEMBL21307534 0.75 ALDH1A1 (0.44) ALDH1A1CYP3A4CYP1A2TP53TSHR
SCHEMBL12607301 0.75 ALDH1A1 (0.48) ALDH1A1CYP3A4CYP1A2TP53TSHR
Ammonia Solution, Strong SCHEMBL3031871 0.74 ALDH1A1 (0.52) ALDH1A1CYP3A4CYP1A2TP53TSHR
SCHEMBL15866070 0.74 ALDH1A1 (0.42) ALDH1A1CYP3A4CYP1A2TP53TSHR
SCHEMBL12324011 0.73 ESR1 (0.37) ALDH1A1CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL26644683 0.73 SHBG (0.38) TDP1HMGB1CXCL12SHBG
SCHEMBL727589 0.73 ALDH1A1 (0.44) ALDH1A1CYP3A4L3MBTL1CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8212078-B2 Making chain extenders with slower cure rates; reacting a ketone and/or aldehyde with a primary amine in the presence of an acidic ion exchange resin and hydrogenation agent; making diimine same way but excluding hydrogenation agent; e.g. N,N'-di-5-nonyl-isophoronediamine ALBEMARLE CORPORATION (US) 2012-07-03 US disclosed
US-7767377-B2 Positive type resist composition, process for forming resist pattern, and process for performing ion implantation TOKYO OHKA KOGYO CO., LTD. (JP) 2010-08-03 US disclosed
US-7767858-B2 Diimines and secondary diamines ALBEMARLE CORPORATION (US) 2010-08-03 US disclosed
EP-2143707-A2 Secondary diamine Albermarle Corporation (US) 2010-01-13 EP disclosed
US-20080194788-A1 Diimines and Secondary Diamines ALBEMARLE CORPORATION (US) 2008-08-14 US disclosed
US-20080033210-A1 DIIMINES AND SECONDARY DIAMINES ALBEMARLE CORPORATION (US) 2008-02-07 US disclosed
US-20080020321-A1 Positive Type Resist Composition, Process for Forming Resist Pattern, and Process for Performing Ion Implantation TOKYO OHKA KOGYO, CO., LTD. (JP) 2008-01-24 US disclosed
US-20080004406-A1 DIIMINES AND SECONDARY DIAMINES ALBEMARLE CORPORATION (US) 2008-01-03 US disclosed
US-7288677-B2 Diimines and secondary diamines ALBEMARLE CORPORATION (US) 2007-10-30 US disclosed
US-20060217567-A1 Diimines and secondary diamines ALBEMARLE CORPORATION 2006-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080004406-A1 DIIMINES AND SECONDARY DIAMINES DDT, DDC, AOC1 ALDH1A1 412/4885CYP3A4 1669/4885L3MBTL1 2969/4885
US-20080033210-A1 DIIMINES AND SECONDARY DIAMINES DDT, DDC, AOC1 ALDH1A1 412/4885CYP3A4 1669/4885L3MBTL1 2969/4885
US-20080194788-A1 Diimines and Secondary Diamines DDT, DDC, AOC1 ALDH1A1 252/4885CYP3A4 1788/4885L3MBTL1 3173/4885
US-20060217567-A1 Diimines and secondary diamines DDT, DDC, AOC1 ALDH1A1 412/4885CYP3A4 1669/4885L3MBTL1 2969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.