Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHAT | P28329 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | DPYD | Q12882 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29627779 | 1.00 | NFE2L2 (0.47) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL30958792 | 0.81 | LMNA (0.62) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL192400 | 0.81 | LMNA (0.62) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL24385991 | 0.81 | LMNA (0.62) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL192399 | 0.81 | LMNA (0.62) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL1232196 | 0.81 | LMNA (0.58) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL4951414 | 0.80 | NFE2L2 (0.50) | NFE2L2TRPA1KMT2AMEN1MAOB | |
| SCHEMBL297693 | 0.80 | NFE2L2 (0.50) | NFE2L2TRPA1KMT2AMEN1MAOB | |
| SCHEMBL897653 | 0.78 | NFE2L2 (0.48) | NFE2L2TRPA1LMNAKMT2AMEN1 | |
| SCHEMBL28051597 | 0.78 | NFE2L2 (0.48) | NFE2L2TRPA1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994137-A1 | HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-05-11 | — | — | EP | claimed |
| EP-3994137-A1 | HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-05-11 | — | — | EP | disclosed |