Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19013577 | 1.00 | NR1H2 (0.43) | NR1H2NR1H3MAP4K1BRAFPIK3CG | |
| SCHEMBL29631985 | 0.91 | ALDH1A1 (0.36) | NR1H2BRAFPIK3CGTP53ALDH1A1 | |
| SCHEMBL18989858 | 0.91 | ALDH1A1 (0.36) | NR1H2BRAFPIK3CGTP53ALDH1A1 | |
| SCHEMBL18990142 | 0.89 | TP53 (0.40) | TP53ALDH1A1HPGDHIF1A | |
| SCHEMBL29631851 | 0.89 | NR1H2 (0.37) | NR1H2NR1H3MAP4K1CA12CA9 | |
| SCHEMBL18989663 | 0.89 | NR1H2 (0.37) | NR1H2NR1H3MAP4K1CA12CA9 | |
| SCHEMBL18990180 | 0.87 | BRAF (0.43) | BRAFPIK3CGTP53ALDH1A1HPGD | |
| SCHEMBL18990001 | 0.87 | ALDH1A1 (0.44) | TP53ALDH1A1 | |
| SCHEMBL18989604 | 0.87 | TNF (0.43) | NR1H2NR1H3ALDH1A1HPGDHIF1A | |
| SCHEMBL29631849 | 0.87 | ALDH1A1 (0.43) | TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187728-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| US-20230067237-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| US-11370792-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2022-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187728-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | MTHFD2, MTHFD1, NUDT15 | NR1H2 2475/4885NR1H3 2703/4885MAP4K1 3755/4885 |
| US-11370792-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | MTHFD2, MTHFD1, NUDT15 | NR1H2 2475/4885NR1H3 2703/4885MAP4K1 3755/4885 |
| US-20230067237-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | MTHFD2, MTHFD1, NUDT15 | NR1H2 2475/4885NR1H3 2703/4885MAP4K1 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.