Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18989858 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MAOAMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL18990142 | 0.92 | TP53 (0.40) | ALDH1A1MAOAMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL19013577 | 0.91 | NR1H2 (0.43) | ALDH1A1TP53BRAFPIK3CGNR1H2 | |
| SCHEMBL29631964 | 0.91 | NR1H2 (0.43) | ALDH1A1TP53BRAFPIK3CGNR1H2 | |
| SCHEMBL29631905 | 0.89 | ALDH1A1 (0.34) | ALDH1A1MAOAMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL18991062 | 0.89 | ALDH1A1 (0.34) | ALDH1A1MAOAMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL18990307 | 0.88 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPSR1ALOX15L3MBTL1 | |
| SCHEMBL29631930 | 0.88 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPSR1ALOX15L3MBTL1 | |
| SCHEMBL18989689 | 0.88 | BRAF (0.39) | ALDH1A1MAOAMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL20592324 | 0.88 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPSR1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187728-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| US-20230067237-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| US-11370792-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | RAZE THERAPEUTICS, INC. (US) | 2022-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187728-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | MTHFD2, MTHFD1, NUDT15 | ALDH1A1 260/4885MAOA 608/4885MAOB 276/4885 |
| US-11370792-B2 | Caffeine inhibitors of MTHFD2 and uses thereof | MTHFD2, MTHFD1, NUDT15 | ALDH1A1 260/4885MAOA 608/4885MAOB 276/4885 |
| US-20230067237-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | MTHFD2, MTHFD1, NUDT15 | ALDH1A1 260/4885MAOA 608/4885MAOB 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.