SCHEMBL29634435

SCHEMBL29634435

c1ccc(-c2n[nH]c3c2oc2ccccc23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 3/20 1.00
MAPT P10636 2/20 1.00
FLT3 P36888 2/20 1.00
MEN1 O00255 1/20 1.00
PDGFRB P09619 1/20 1.00
KIT P10721 1/20 1.00
KMT2A Q03164 1/20 1.00
HDAC6 Q9UBN7 1/20 1.00
ALDH1A1 P00352 7/20 0.49
KDM4E B2RXH2 4/20 0.49
GAA P10253 3/20 0.49
HPGD P15428 3/20 0.49
ALPL P05186 1/20 0.49
IDO1 P14902 1/20 0.49
TTK P33981 1/20 0.49
MAPK10 P53779 1/20 0.49
ATM Q13315 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HSD17B10 Q99714 2/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2550165 1.00 CSF1R (1.00) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL6996466 0.77 KMT2A (0.61) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL11127257 0.76 MAPT (0.61) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL13102148 0.75 MEN1 (0.60) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL20670037 0.74 MAPT (0.57) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL18122029 0.68 ALDH1A1 (0.55) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL24796192 0.68 MAPT (0.51) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL18774623 0.68 ERCC5 (0.56) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL18121538 0.67 ALDH1A1 (0.53) CSF1RMAPTFLT3MEN1PDGFRB
SCHEMBL17306394 0.67 ALDH1A1 (0.53) CSF1RMAPTFLT3MEN1PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636370-B2 Combination therapy for treatment of cancer INSTITUTE FOR CANCER RESEARCH (US) 2026-05-26 US disclosed
EP-4715066-A1 PANEL OF MICRORNAS AS BIOMARKERS OF NON-SEGMENTAL VITILIGO Servicio Andaluz De Salud (ES) 2026-03-25 EP disclosed
US-12534764-B2 Crenolanib for treating FLT3 mutated proliferative disorders associated mutations AROG PHARMACEUTICALS, INC. (US) 2026-01-27 US disclosed
US-20250345322-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS AROG PHARMACEUTICALS INC (US) 2025-11-13 US disclosed
US-20250305063-A1 Crenolanib for Treating FLT3 Mutated Proliferative Disorders Associated Mutations AROG PHARMACEUTICALS, INC. 2025-10-02 US disclosed
US-12404555-B2 Crenolanib for treating FLT3 mutated proliferative disorders associated mutations AROG PHARMACEUTICALS, INC. (US) 2025-09-02 US disclosed
US-12383549-B2 Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders AROG PHARMACEUTICALS, INC. (US) 2025-08-12 US disclosed
US-20250161293-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT AROG PHARMACEUTICALS, INC. 2025-05-22 US disclosed
US-12295948-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment AROG PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
US-20250078957-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2025-03-06 US disclosed
WO-2023158713-A1 UNSUPERVISED MACHINE LEARNING METHODS AMPEL BIOSOLUTIONS, LLC (US) 2023-08-24 WO disclosed
WO-2023102379-A1 COMBINATION THERAPY FOR CANCER TREATMENT INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER (US) 2023-06-08 WO disclosed
US-20230128591-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT AROG PHARMACEUTICALS, INC. 2023-04-27 US disclosed
US-20230011378-A1 Combination Therapy For Treatment Of Cancer INSTITUTE FOR CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER 2023-01-12 US disclosed
US-20220409610-A1 Crenolanib for Treating FLT3 Mutated Proliferative Disorders AROG PHARMACEUTICALS, INC. 2022-12-29 US disclosed
US-11458131-B2 Crenolanib for treating FLT3 mutated proliferative disorders AROG PHARMACEUTICALS, INC. (US) 2022-10-04 US disclosed
US-11440880-B2 Thalidomide analogs and methods of use THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-09-13 US disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220218694-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS ASSOCIATED MUTATIONS AROG PHARMACEUTICALS, INC. 2022-07-14 US disclosed
US-20220133710-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS AROG PHARMACEUTICALS, INC. 2022-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250345322-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS CCAR2, BAX, DUSP22 CSF1R 1404/4885MAPT 3662/4885FLT3 2173/4885
US-20250305063-A1 Crenolanib for Treating FLT3 Mutated Proliferative Disorders Associated Mutations FLT3, RET, CSF1R CSF1R 3/4885MAPT 4440/4885FLT3 1/4885
US-12295948-B2 Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment FLT3, RET, MKI67 CSF1R 12/4885MAPT 3372/4885FLT3 1/4885
US-11458131-B2 Crenolanib for treating FLT3 mutated proliferative disorders FLT3, FLT1, RET CSF1R 6/4885MAPT 2265/4885FLT3 1/4885
US-12636370-B2 Combination therapy for treatment of cancer RB1, MDM2, PHKB CSF1R 747/4885MAPT 1427/4885FLT3 1586/4885
US-20230011378-A1 Combination Therapy For Treatment Of Cancer CDK9, KRAS, BRD9 CSF1R 1274/4885MAPT 2260/4885FLT3 810/4885
US-20230128591-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT FLT3, RET, MKI67 CSF1R 12/4885MAPT 3372/4885FLT3 1/4885
US-12404555-B2 Crenolanib for treating FLT3 mutated proliferative disorders associated mutations FLT3, RET, CSF1R CSF1R 3/4885MAPT 4440/4885FLT3 1/4885
US-12534764-B2 Crenolanib for treating FLT3 mutated proliferative disorders associated mutations FLT3, NUP188, KPNB1 CSF1R 38/4885MAPT 3077/4885FLT3 1/4885
US-20250161293-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS RELAPSED/REFRACTORY TO PRIOR TREATMENT FLT3, RET, MKI67 CSF1R 12/4885MAPT 3372/4885FLT3 1/4885
US-11440880-B2 Thalidomide analogs and methods of use PGF, TYMP, TPMT CSF1R 796/4885MAPT 2830/4885FLT3 543/4885
US-12383549-B2 Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders CCAR2, BAX, TP53 CSF1R 1851/4885MAPT 3306/4885FLT3 2042/4885
US-20220133710-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS CCAR2, BAX, DUSP22 CSF1R 1404/4885MAPT 3662/4885FLT3 2173/4885
US-20220409610-A1 Crenolanib for Treating FLT3 Mutated Proliferative Disorders FLT3, FLT1, RET CSF1R 6/4885MAPT 2265/4885FLT3 1/4885
US-20220218694-A1 CRENOLANIB FOR TREATING FLT3 MUTATED PROLIFERATIVE DISORDERS ASSOCIATED MUTATIONS FLT3, RUNX1, RET CSF1R 8/4885MAPT 4354/4885FLT3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.