Anabasine

Anabasine

SCHEMBL29634446

c1cncc([C@@H]2CCCCN2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 10/20 1.00
CHRNA4 P43681 10/20 1.00
CHRNA7 P36544 8/20 1.00
CYP2A6 P11509 3/20 1.00
MEN1 O00255 2/20 1.00
CYP2D6 P10635 2/20 1.00
CYP2C19 P33261 2/20 1.00
KMT2A Q03164 2/20 1.00
POLB P06746 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP11B2 P19099 1/20 0.58
AURKA O14965 1/20 0.47
ALDH1A1 P00352 2/20 0.45
CHRNB4 P30926 2/20 0.45
CHRNA3 P32297 2/20 0.45
CHRNA2 Q15822 2/20 0.45
LMNA P02545 1/20 0.45
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Anabasine SCHEMBL15740333 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL30835558 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL117530 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Anabasine SCHEMBL3465120 1.00 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL9673975 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL9673965 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Anabasine SCHEMBL29421176 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL1004341 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL6801148 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
Dl-Anabasine SCHEMBL7194509 0.98 CHRNB2 (0.97) CHRNB2CHRNA4CHRNA7CYP2A6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114831335-A Application of anabasine in atomized electronic delivery product 汪冶 2022-08-02 CN claimed
CN-114732148-A Application of anabasine in heating non-combustion electron delivery product, solid-state slice and preparation method thereof 汪冶 2022-07-12 CN claimed
CN-122030529-A Traditional Chinese medicine preparation of children's heightening and intelligence-improving beverage and preparation method thereof 佳乐(山东)控股有限公司 2026-05-15 CN disclosed
US-12538922-B2 Composition and methods for parasite control PHILIP MORRIS PRODUCTS S.A. (CH) 2026-02-03 US disclosed
US-20250243178-A1 3-(1,2,3,6-TETRAHYDROPYRIDIN-2-YL) PYRIDINE GLUTARATE OR A PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF PHILIP MORRIS PRODUCTS S.A. (CH) 2025-07-31 US disclosed
US-12281093-B2 3-(1,2,3,6-tetrahydropyridin-2-YL) pyridine glutarate or a pharmaceutically acceptable solvate thereof PHILIP MORRIS PRODUCTS S.A. (CH) 2025-04-22 US disclosed
CN-115485386-B Tobacco plant body with low alkaloid content and preparation method thereof 日本烟草产业株式会社 2024-03-29 CN disclosed
CN-110072842-B Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2024-02-02 CN disclosed
CN-113980978-B Tobacco nicotine transporter related gene and application thereof 云南中烟工业有限责任公司 2023-12-26 CN disclosed
CN-110505874-B Molecules having pesticidal utility, and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2023-09-26 CN disclosed
US-20220400674-A1 COMPOSITION AND METHODS FOR PARASITE CONTROL PHILIP MORRIS PRODUCTS S.A. (CH) 2022-12-22 US disclosed
US-11452293-B2 (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2022-09-27 US disclosed
CN-114831335-A Application of anabasine in atomized electronic delivery product 汪冶 2022-08-02 CN disclosed
CN-114732148-A Application of anabasine in heating non-combustion electron delivery product, solid-state slice and preparation method thereof 汪冶 2022-07-12 CN disclosed
EP-3986131-A1 COMPOSITIONS AND METHODS FOR PARASITE CONTROL Philip Morris Products, S.A. (CH) 2022-04-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12281093-B2 3-(1,2,3,6-tetrahydropyridin-2-YL) pyridine glutarate or a pharmaceutically acceptable solvate thereof ADH1A, GRHPR, GLS2 CHRNB2 3750/4885CHRNA4 2636/4885CHRNA7 2282/4885
US-12538922-B2 Composition and methods for parasite control CAT, CTRL, NOX1 CHRNB2 1244/4885CHRNA4 799/4885CHRNA7 479/4885
US-20220400674-A1 COMPOSITION AND METHODS FOR PARASITE CONTROL C5, NOX5, CYCS CHRNB2 3535/4885CHRNA4 3369/4885CHRNA7 2554/4885
US-20250243178-A1 3-(1,2,3,6-TETRAHYDROPYRIDIN-2-YL) PYRIDINE GLUTARATE OR A PHARMACEUTICALLY ACCEPTABLE SOLVATE THEREOF GLS2, ADH1A, GRHPR CHRNB2 3588/4885CHRNA4 2543/4885CHRNA7 2183/4885
US-11452293-B2 (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using AAAS, NANS, CIAPIN1 CHRNB2 2259/4885CHRNA4 2648/4885CHRNA7 2246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.