Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491518 | 0.83 | RAB9A (0.35) | TSHRCNR2ALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL28123899 | 0.82 | MAPT (0.39) | TSHRMAPTLMNACYP1A2CYP2D6 | |
| SCHEMBL815789 | 0.82 | CRHR1 (0.36) | ALDH1A1ALDH1A3ALDH3A1 | |
| SCHEMBL31718395 | 0.82 | TSHR (0.46) | TSHRCNR2ALDH1A1GAAMAPT | |
| SCHEMBL6299189 | 0.82 | TSHR (0.46) | TSHRCNR2ALDH1A1GAAMAPT | |
| SCHEMBL2962157 | 0.79 | TDP1 (0.38) | TSHRALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL2489419 | 0.77 | DDB1 (0.35) | TSHRALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL2464159 | 0.76 | SIGMAR1 (0.31) | — | |
| SCHEMBL30311684 | 0.75 | TSHR (0.41) | TSHRCNR2ALDH1A1GAAMAPT | |
| SCHEMBL2326737 | 0.75 | TSHR (0.41) | TSHRCNR2ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117677382-A | Benzyloxy benzylamino amino acid derivatives that modulate TSLP/TSLPR signaling | 阿米蒂比奥有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-110325509-B | Functional derivative compounds of alanine and proline amino acids and pharmaceutical compositions containing the same | 阿米蒂比奥有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-114716386-A | Novel exosome inhibitor and preparation method thereof | 北京和理咨询有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-110325509-A | Functional derivative compound of alanine and proline amino acid and pharmaceutical composition containing same | 阿米蒂比奥有限公司 | 2019-10-11 | — | — | CN | claimed |
| US-9809822-B2 | Triptolide derivatives and preparation method and use thereof | HONG KONG BAPTIST UNIVERSITY (HK) | 2017-11-07 | — | — | US | claimed |
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | HONG KONG BAPTIST UNIVERSITY (HK) | 2016-12-15 | — | — | US | claimed |
| EP-0837855-A4 | METHOD FOR PREPARING N-MONOSUBSTITUTED AND N,N'-DISUBSTITUTED UNSYMMETRICAL CYCLIC UREAS | DU PONT MERCK PHARMA (US) | 1998-09-02 | — | — | EP | claimed |
| EP-0837855-A1 | METHOD FOR PREPARING N-MONOSUBSTITUTED AND N,N'-DISUBSTITUTED UNSYMMETRICAL CYCLIC UREAS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-04-29 | — | — | EP | claimed |
| WO-1996040652-A1 | METHOD FOR PREPARING N-MONOSUBSTITUTED AND N,N'-DISUBSTITUTED UNSYMMETRICAL CYCLIC UREAS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-19 | — | — | WO | claimed |
| US-5532357-A | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-02 | — | — | US | claimed |
| CN-117677382-A | Benzyloxy benzylamino amino acid derivatives that modulate TSLP/TSLPR signaling | 阿米蒂比奥有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-110325509-B | Functional derivative compounds of alanine and proline amino acids and pharmaceutical compositions containing the same | 阿米蒂比奥有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116836083-A | Functional derivative compounds of alanine and proline amino acids and pharmaceutical compositions containing the same | 阿米蒂比奥有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116622005-A | Polymer prodrug compound and preparation method thereof, and polymer prodrug micelle and preparation method thereof | 成都普康生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-114716386-A | Novel exosome inhibitor and preparation method thereof | 北京和理咨询有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-0273426-B1 | ENAMINE DERIVATIVES, PRODUCTION THEREOF AND ELECTROPHOTOGRAPHIC PLATES CONTAINING THE SAME | Hitachi Chemical Co., Ltd. (JP) | 1993-03-17 | — | — | EP | disclosed |
| EP-0435503-A1 | Improvements in or relating to gylcopeptide derivatives | ELI LILLY AND COMPANY (US) | 1991-07-03 | — | — | EP | disclosed |
| EP-0273426-A2 | Enamine derivatives, production thereof and electrophotographic plates containing the same | Hitachi Chemical Co., Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |
| US-4456671-A | Electrophotographic photosensitive member having a photosensitive layer containing a hydrazone compound | CANON KABUSHIKI KAISHA (JP) | 1984-06-26 | — | — | US | disclosed |
| US-4399207-A | Electrophotographic photosensitive member with hydrazone compound | CANON KABUSHIKI KAISHA (JP) | 1983-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362691-A1 | TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | TPD52L2, TRDMT1, MCTS1 | TSHR 325/4885CNR2 4127/4885ALDH1A1 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.