Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638354 | 1.00 | NPC1 (0.35) | NPC1TYK2JAK1AKR1C3MAPT | |
| SCHEMBL29638374 | 0.86 | PLK1 (0.34) | TYK2JAK1MAPTALDH1A1LMNA | |
| SCHEMBL29638457 | 0.86 | SLC34A1 (0.34) | TYK2JAK1MAPT | |
| SCHEMBL29638381 | 0.82 | MAPK1 (0.33) | TYK2JAK1MAPT | |
| SCHEMBL29638370 | 0.81 | PLK1 (0.44) | TYK2JAK1MAPTPIK3CD | |
| SCHEMBL29638348 | 0.80 | PLK1 (0.34) | TYK2JAK1MAPT | |
| SCHEMBL29638384 | 0.72 | AKR1C3 (0.39) | TYK2JAK1AKR1C3TP53ALDH1A1 | |
| SCHEMBL29638408 | 0.71 | PLK1 (0.36) | TYK2MAPTTP53ALDH1A1HPGD | |
| SCHEMBL29638349 | 0.65 | PTGS2 (0.38) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL24557281 | 0.65 | KMT2A (0.39) | TYK2JAK1AKR1C3MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |