Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638418 | 0.92 | ABL1 (0.44) | ABL1GSK3BKMT2ATP53NPC1 | |
| SCHEMBL29638459 | 0.90 | ABL1 (0.55) | ABL1GSK3BKMT2AMEN1 | |
| SCHEMBL29638359 | 0.87 | KDR (0.49) | GSK3B | |
| SCHEMBL29638385 | 0.86 | ABL1 (0.47) | ABL1GSK3BNPC1RAB9A | |
| SCHEMBL24557247 | 0.86 | ABL1 (0.48) | ABL1GSK3BNPC1RAB9AGSK3A | |
| SCHEMBL29638324 | 0.85 | ALKBH5 (0.41) | ABL1GSK3BKMT2ATP53NPC1 | |
| SCHEMBL29638419 | 0.83 | TRPV1 (0.50) | ABL1JAK2TRPV1 | |
| SCHEMBL29638378 | 0.82 | TYK2 (0.46) | ABL1GSK3BKMT2AMEN1JAK2 | |
| SCHEMBL29638373 | 0.81 | MAP4K1 (0.48) | ABL1GSK3B | |
| SCHEMBL24557310 | 0.81 | PIK3CD (0.46) | ABL1GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |