Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23362964 | 1.00 | GAA (0.44) | GAAKMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL10746305 | 0.87 | CA2 (0.52) | GAAKMT2AALDH1A1HSD17B10CASP1 | |
| SCHEMBL2778087 | 0.84 | GAA (0.44) | GAAKMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL517916 | 0.80 | L3MBTL1 (0.45) | KMT2AL3MBTL1MAPTALDH1A1HPGD | |
| SCHEMBL31648415 | 0.78 | L3MBTL1 (0.46) | L3MBTL1MAPTALDH1A1HPGDTDP1 | |
| SCHEMBL1810628 | 0.77 | GAA (0.58) | GAAKMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL28882436 | 0.75 | ALDH1A1 (0.45) | L3MBTL1MAPTALDH1A1HPGDTDP1 | |
| SCHEMBL16119617 | 0.75 | HTR7 (0.51) | MAPTALDH1A1LMNA | |
| SCHEMBL10667947 | 0.75 | MAPT (0.48) | GAAKMT2AL3MBTL1MAPTALDH1A1 | |
| SCHEMBL9044971 | 0.75 | MAPK1 (0.56) | KMT2AL3MBTL1ALDH1A1TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641477-B | Compounds having inhibitory activity on glucosylceramide synthase or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the same | 柳韩洋行 | 2024-03-12 | — | — | CN | disclosed |
| CN-114641477-A | Novel compound having inhibitory activity against glucose ceramide synthase or pharmaceutically acceptable salt thereof, method for preparing same, and pharmaceutical composition comprising same | 柳韩洋行 | 2022-06-17 | — | — | CN | disclosed |