Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 3/20 | 0.33 |
| ▸ | GABRD | O14764 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24584512 | 1.00 | MCHR1 (0.42) | MCHR1SLC2A1NOS3NOS1NOS2 | |
| SCHEMBL22234714 | 0.83 | ALOX5AP (0.38) | MCHR1NOS3NOS1NOS2ALOX5AP | |
| SCHEMBL15527772 | 0.78 | LMNA (0.41) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL20557567 | 0.77 | ALDH1A1 (0.45) | NOS3NOS1NOS2 | |
| SCHEMBL22834443 | 0.76 | TRPC6 (0.45) | NOS3NOS1NOS2ALOX5APFEN1 | |
| SCHEMBL22259430 | 0.76 | CNR2 (0.34) | NOS3NOS1NOS2ALOX5APFEN1 | |
| Bromide SCHEMBL19950848 | 0.76 | LMNA (0.40) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL22834465 | 0.76 | PDE4A (0.35) | NOS3NOS1NOS2ALOX5APFEN1 | |
| SCHEMBL18050648 | 0.74 | MET (0.49) | MCHR1SLC2A1CCNA2CDK2CCNA1 | |
| SCHEMBL24584511 | 0.74 | GABRP (0.42) | MCHR1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116867781-A | Imidazo [1,2-a ] pyridine derivatives as IRAK4 inhibitors and their use in the treatment of diseases | 渤健马萨诸塞州股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| WO-2022140425-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE | BIOGEN MA INC. (US) | 2022-06-30 | — | — | WO | disclosed |