SCHEMBL29642252

SCHEMBL29642252

Cc1cc(C=O)ccc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.47
ALDH1A3 P47895 2/20 0.47
CYP2A6 P11509 1/20 0.46
GABRA1 P14867 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
TSHR P16473 1/20 0.42
PTGS2 P35354 2/20 0.41
KDM4E B2RXH2 1/20 0.41
RAB9A P51151 1/20 0.41
HSD17B10 Q99714 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
NFE2L2 Q16236 1/20 0.41
KIF11 P52732 1/20 0.39
HPGD P15428 2/20 0.38
AOX1 Q06278 1/20 0.38
TRIM24 O15164 1/20 0.38
ALDH5A1 P51649 1/20 0.38
ABAT P80404 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL336067 1.00 ALDH1A1 (0.47) ALDH1A1ALDH1A3CYP2A6GABRA1SIGMAR1
SCHEMBL18002878 0.87 NFE2L2 (0.47) ALDH1A1ALDH1A3PTGS2NFE2L2ALOX5
SCHEMBL2012322 0.84 KIF11 (0.54) CYP2A6PTGS2HSD17B10KIF11PTGS1
SCHEMBL229897 0.82 ALDH1A1 (0.47) ALDH1A1ALDH1A3CYP2A6SMN1; SMN2TSHR
SCHEMBL29453098 0.82 ALDH1A1 (0.47) ALDH1A1ALDH1A3CYP2A6SMN1; SMN2TSHR
SCHEMBL5734344 0.79 TRIM24 (0.50) ALDH1A1PTGS2KIF11TRIM24TRIM33
SCHEMBL14667747 0.79 ALDH1A1 (0.46) ALDH1A1ALDH1A3CYP2A6SMN1; SMN2KDM4E
SCHEMBL48607 0.78 ALDH1A1 (0.52) ALDH1A1CYP2A6SMN1; SMN2TSHRPTGS2
SCHEMBL29389102 0.78 ALDH1A1 (0.52) ALDH1A1CYP2A6SMN1; SMN2TSHRPTGS2
SCHEMBL98097 0.78 CYP2A6 (0.52) ALDH1A1ALDH1A3CYP2A6TSHRPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4398902-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF AMYLOID PEPTIDE INTERACTIONS WITH GLYCOSAMINOGLYCANS, METHODS OF TREATMENT, AND USE THEREOF Gismo Therapeutics, Inc. (US) 2024-07-17 EP disclosed
WO-2023038876-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF AMYLOID PEPTIDE INTERACTIONS WITH GLYCOSAMINOGLYCANS, METHODS OF TREATMENT, AND USE THEREOF GISMO THERAPEUTICS, INC. (US) 2023-03-16 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
EP-3239135-B1 PYRIMIDONE COMPOUNDS USED AS LP-PLA2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2022-05-04 EP disclosed