Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29642252 | 1.00 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3CYP2A6GABRA1SIGMAR1 | |
| SCHEMBL18002878 | 0.87 | NFE2L2 (0.47) | ALDH1A1ALDH1A3PTGS2NFE2L2ALOX5 | |
| SCHEMBL2012322 | 0.84 | KIF11 (0.54) | CYP2A6PTGS2HSD17B10KIF11PTGS1 | |
| SCHEMBL229897 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3CYP2A6SMN1; SMN2TSHR | |
| SCHEMBL29453098 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3CYP2A6SMN1; SMN2TSHR | |
| SCHEMBL5734344 | 0.79 | TRIM24 (0.50) | ALDH1A1PTGS2KIF11TRIM24TRIM33 | |
| SCHEMBL14667747 | 0.79 | ALDH1A1 (0.46) | ALDH1A1ALDH1A3CYP2A6SMN1; SMN2KDM4E | |
| SCHEMBL48607 | 0.78 | ALDH1A1 (0.52) | ALDH1A1CYP2A6SMN1; SMN2TSHRPTGS2 | |
| SCHEMBL29389102 | 0.78 | ALDH1A1 (0.52) | ALDH1A1CYP2A6SMN1; SMN2TSHRPTGS2 | |
| SCHEMBL98097 | 0.78 | CYP2A6 (0.52) | ALDH1A1ALDH1A3CYP2A6TSHRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 718 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117865959-A | 2- (4-fluoro) -phenyl-6-cyclopropyl-5, 6,7, 8-tetrahydropyrido pyrimidine derivative and synthesis and application thereof | 西华大学 | 2024-04-12 | — | — | CN | claimed |
| CN-117865958-A | 4-phenyl-8 styryl substituted pyrimidopyridine benzamide compound and synthesis and application thereof | 西华大学 | 2024-04-12 | — | — | CN | claimed |
| CN-117865957-A | 2-phenyl-4-phenyl-6-N-isopropyl substituted pyrimidopyridine derivative and synthesis and application thereof | 西华大学 | 2024-04-12 | — | — | CN | claimed |
| CN-114349656-B | Preparation method of hydrazide compound | 赣南师范大学 | 2024-03-29 | — | — | CN | claimed |
| CN-117050112-A | DOPO derivative containing benzazepine as well as preparation method and application thereof | 西华大学 | 2023-11-14 | — | — | CN | claimed |
| CN-114409595-A | 1-styryl isoquinoline derivative and preparation and application thereof | 南华大学附属第一医院 | 2022-04-29 | — | — | CN | claimed |
| CN-111793371-B | 3, 5-asymmetrically modified BODIPY near-infrared fluorescent dye and preparation method thereof | 南京林业大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111793371-A | 3, 5-asymmetrically modified BODIPY near-infrared fluorescent dye and preparation method thereof | 南京林业大学 | 2020-10-20 | — | — | CN | claimed |
| CN-107188851-B | Method for synthesizing astemizole key intermediate and derivative thereof | 湖南大学 | 2020-04-07 | — | — | CN | claimed |
| EP-2199290-B1 | Method of nucleating a polyolefin composition with acetal-based compounds | MILLIKEN & CO (US) | 2018-06-06 | — | — | EP | claimed |
| US-6451830-B1 | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. | 2002-09-17 | — | — | US | claimed |
| US-6448295-B1 | TREATING CARDIOVASCULAR DISEASE; ATHEROSCLEROSIS, DYSLIPIDEMA HYPERCHOLESTEROLAEMIA; DECREASING CONCENTRATIONS OF LOW DENSITY LIPOPROTEIN AND RAISING LEVEL OF HIGH DENSITY LIPOPROTEIN | G.D. SEARLE & CO. | 2002-09-10 | — | — | US | claimed |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | SIKORSKI JAMES A (US) | 2002-08-29 | — | — | US | claimed |
| US-20010018446-A1 | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. (US) | 2001-08-30 | — | — | US | claimed |
| EP-1115695-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| EP-1115693-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| EP-1115694-A1 | SUBSTITUTED N-ALIPHATIC-N-AROMATIC (TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | claimed |
| WO-2000018724-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(n+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
| WO-2000018723-A1 | SUBSTITUTED N-ALIPHATIC-N-AROMATIC TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
| WO-2000018721-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018446-A1 | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity | CETP, DBI, MTTP | ALDH1A1 2624/4885ALDH1A3 4380/4885CYP2A6 3016/4885 |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | CETP, PCTP, DBI | ALDH1A1 2895/4885ALDH1A3 4275/4885CYP2A6 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.