SCHEMBL29644895

SCHEMBL29644895

COc1cccc(NC(=O)/C=C/c2ccc3c(c2)C=CC(C)(C)O3)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 4/20 0.60
MMP2 P08253 4/20 0.60
MMP9 P14780 4/20 0.60
KMT2A Q03164 6/20 0.58
MAPT P10636 6/20 0.58
MEN1 O00255 5/20 0.58
ALDH1A1 P00352 5/20 0.58
TRPV1 Q8NER1 4/20 0.58
TP53 P04637 2/20 0.58
HDAC6 Q9UBN7 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2C9 P11712 1/20 0.58
TSHR P16473 1/20 0.58
MAPK1 P28482 1/20 0.58
CYP2C19 P33261 1/20 0.58
NPC1 O15118 5/20 0.57
RAB9A P51151 5/20 0.57
TDP1 Q9NUW8 1/20 0.57
SMN1; SMN2 Q16637 6/20 0.55
NFKB1 P19838 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29644898 0.89 MAPT (0.61) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644884 0.87 TRPV1 (0.61) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644890 0.87 PTPN1 (0.59) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644900 0.87 PTPN1 (0.59) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644891 0.83 RAB9A (0.62) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644902 0.82 KDM1A (0.61) KMT2AMAPTMEN1TRPV1PTPN1
SCHEMBL29644889 0.80 MAPT (0.56) MMP1MMP2MMP9KMT2AMAPT
SCHEMBL29644901 0.80 XDH (0.62) MMP1MMP2MMP9PTPN1
SCHEMBL29644899 0.79 PTPN1 (0.61) MMP1MMP2MMP9TRPV1PTPN1
SCHEMBL29644903 0.78 KDM4E (0.63) KMT2AMAPTMEN1ALDH1A1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109096235-B 2, 2-dimethyl benzopyran derivative and preparation method and application thereof 沈阳药科大学 2022-06-21 CN disclosed