SCHEMBL29644902

SCHEMBL29644902

COc1cc(/C=C/C(=O)Nc2ccc3c(c2)C=CC(C)(C)O3)ccc1O

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 13/20 0.61
ODC1 P11926 2/20 0.59
TRPV1 Q8NER1 1/20 0.54
PTPN1 P18031 1/20 0.54
MEN1 O00255 1/20 0.52
POLB P06746 1/20 0.52
MAPT P10636 1/20 0.52
KMT2A Q03164 1/20 0.52
CA12 O43570 1/20 0.52
CA9 Q16790 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29644901 0.89 XDH (0.62) PTPN1CA12CA9
SCHEMBL29644884 0.86 TRPV1 (0.61) TRPV1PTPN1MEN1MAPTKMT2A
SCHEMBL29644899 0.85 PTPN1 (0.61) ODC1TRPV1PTPN1CA12CA9
SCHEMBL29644898 0.84 MAPT (0.61) TRPV1PTPN1MEN1MAPTKMT2A
SCHEMBL14606067 0.83 ODC1 (0.68) ODC1PTPN1
SCHEMBL29644895 0.82 MMP1 (0.60) TRPV1PTPN1MEN1MAPTKMT2A
SCHEMBL29644889 0.81 MAPT (0.56) PTPN1MEN1POLBMAPTKMT2A
SCHEMBL29644903 0.81 KDM4E (0.63) TRPV1PTPN1MEN1POLBMAPT
SCHEMBL5599975 0.81 ODC1 (0.65) ODC1PTPN1
SCHEMBL29644891 0.80 RAB9A (0.62) KDM1AODC1TRPV1PTPN1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109096235-B 2, 2-dimethyl benzopyran derivative and preparation method and application thereof 沈阳药科大学 2022-06-21 CN disclosed