Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655763 | 0.86 | PTGER4 (0.46) | PTGER4RXRAHNF4AIDO1TDO2 | |
| SCHEMBL30353241 | 0.83 | PKM (0.40) | PTGER4RXRARARARARBRARG | |
| SCHEMBL29655790 | 0.82 | PLK1 (0.46) | PTGER4RXRABAZ2BPLK1HNF4A | |
| SCHEMBL29696137 | 0.75 | CYP26A1 (0.47) | PTGER4GAARXRARARARARB | |
| SCHEMBL7981477 | 0.70 | GAA (0.55) | GAAPLK1HPGDMAPK1 | |
| SCHEMBL29655785 | 0.68 | CYP26A1 (0.46) | PTGER4GAARXRARARARARB | |
| SCHEMBL29655733 | 0.68 | PLK1 (0.42) | PTGER4GAAPLK1NPC1RAB9A | |
| SCHEMBL31474132 | 0.66 | KDM4E (0.41) | RARBRARGIDO1TDO2NPC1 | |
| SCHEMBL12506962 | 0.66 | GAA (0.50) | GAAPLK1NPC1RAB9A | |
| SCHEMBL13575596 | 0.65 | GAA (0.48) | GAAPLK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138793-A1 | COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST | 小野薬品工業株式会社 | 2022-06-30 | — | — | WO | disclosed |
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |