Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655802 | 0.82 | PTGER4 (0.43) | PLK1PTGER4RXRAHNF4ANPC1 | |
| SCHEMBL29696137 | 0.73 | CYP26A1 (0.47) | PLK1PTGER4RXRAPKMNPC1 | |
| SCHEMBL29655763 | 0.71 | PTGER4 (0.46) | PTGER4RXRAHNF4ANPC1TP53 | |
| SCHEMBL30353241 | 0.70 | PKM (0.40) | PTGER4RXRAHNF4APKMNPC1 | |
| SCHEMBL7954427 | 0.69 | CYP3A4 (0.57) | PLK1PKMNPC1RAB9AMAPT | |
| SCHEMBL29655733 | 0.66 | PLK1 (0.42) | PLK1PTGER4PKMNPC1RAB9A | |
| SCHEMBL29655785 | 0.66 | CYP26A1 (0.46) | PLK1PTGER4RXRAPKMNPC1 | |
| SCHEMBL34460242 | 0.65 | IRAK4 (0.36) | RXRA | |
| SCHEMBL29655815 | 0.65 | SMN1; SMN2 (0.47) | PTGER4NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL31371949 | 0.64 | DRD2 (0.44) | MAPTALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022138793-A1 | COMBINATION BETWEEN EP2 RECEPTOR ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR AND/OR EP4 RECEPTOR ANTAGONIST | 小野薬品工業株式会社 | 2022-06-30 | — | — | WO | disclosed |
| WO-2022102731-A1 | CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR | 小野薬品工業株式会社 | 2022-05-19 | — | — | WO | disclosed |